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Novel cytotoxic and antitumor agents. IV. Withaferin A: relation of its structure to the in vitro cytotoxic effects on P388 cells.
In vitro effects of withaferin A and its 9 new derivatives on P388 cells have been studied. The cytotoxicity was calculated from the utilization of precursors in protein and nucleic acid (NA)… Expand
Bikaverin, an antibiotic from ibberella fujikoi, effective against Leishmania brasiliensis.
New potential cytotoxic and antitumor substances I. In vitro effect of bikaverin and its derivatives on cells of certain tumors.
Bikaverin and its derivatives have been found to affect precursor utilization of nucleic acid and protein synthesis in the cells of Ehrlich ascites carcinoma (EAC). Mainly the uridine incorporation… Expand
Metabolites of Pseudevernia furfuracea (L.) Zopf. and their inhibition potential of proteolytic enzymes.
Atranorin (1), physodic acid (2), oxyphysodic acid (3) and virensic (4) acid were identified in P. furfuracea, a lichen species collected in West Tatra. According to HPLC analysis contents of these… Expand
Effects of bikaverin on purine nucleotide synthesis and catabolism in Ehrlich ascites tumor cells in vitro.
- J. Henderson, M. L. Battell, G. Zombor, J. Fuska, P. Nemec
- Biology, Medicine
- Biochemical pharmacology
- 1 November 1977
Abstract Bikaverin, a growth-inhibitory fungal metabolite, inhibits the incorporation of radioactive purine bases into nucleic acids and also into acid-soluble nucleotides. It also inhibits energy… Expand
Bikaverin, an antibiotic fromGibberella fujikuroi, effective againstLeishmania brasiliensis
The red quinone C20H14O8 (mp 322–324), named bikaverin was isolated from mycelium ofGibberella fujikuroi. Bikaverin is specifically effective againstLeishmania brasiliensis while is not effective… Expand
Effect of colicin E3 on leukemia cells P 388 in vitro
Proliferation of murine leukemia cells P388 is stimulated by less than 1.0 mg/ml colicin E3, while being inhibited by higher concentrations. By 1.6 mg/ml colicin E3, uptake of thymidine into cold… Expand
Vermicillin, a new metabolite from Penicillium vermiculatum inhibiting tumor cells in vitro.
Sir: In the systematic research for metabolites effective against tumor cells, the antibiotics, vermiculine1) and vermistatinz2), effective against P 388 cells have been isolated from the filtrate of… Expand
The antibiotic PSX-1 Produced byPennicilium stipitatum is identical with botryodiplodin
Antibiotic PSX-1 exhibiting antitumour activity, formerly isolated from the filtrate of a culture ofPenicillium stipitatum, was shown to be identical with botryodiplodin.
(-)-Mitorubrinol and Phthaldehydic Acids, New Metabolites of Penicillium vermiculatum DANG.
Three new metabolites - (-)-mitorubrinol, 2-formyl-3,5-dihydroxy-4-methylbenzoic and 2-formyl-3,5-dihydroxy-4-hydroxymethylbenzoic acids - were isolated from the culture medium of Penicillium… Expand