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Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
TLDR
Impaired RHOA function in cooperation with preceding loss of TET2 function contributes to AITL-specific pathogenesis, and it is demonstrated that the Gly17Val RHOA mutant did not bind GTP and also inhibited wild-typeRHOA function. Expand
Promoter methylation profiling of 30 genes in human malignant melanoma
TLDR
These profiles showed that both aberrant methylation and demethylation occur widely in human melanomas. Expand
Identification of 27 5′ CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers
TLDR
Aberrantly methylated DNA fragments were searched for in human pancreatic cancers, using the genome scanning technique: methylation-sensitive-representational difference analysis (MS-RDA), and some were suggested to be potentially involved in pancreatic cancer development and progression. Expand
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.
TLDR
A genome-wide search using methylation-sensitive representational difference analysis found CGIs in putative promoter regions of 34 genes, and among these genes, Peroxiredoxin 2 (PRDX2) was expressed in normal melanocytes, and its expression was lost in melanomas with methylation. Expand
Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice.
TLDR
Findings indicate that the Nrf2-Keap1 pathway plays an important role in protection of the skin against acute UVB reactions, including cutaneous cell apoptosis and oxidative damage. Expand
Decreased fidelity in replicating DNA methylation patterns in cancer cells leads to dense methylation of a CpG island.
TLDR
It was shown that methylated status of a CpG site was more stably inherited than unmethylated status, suggesting that the genome is constantly exposed to de novo methylation. Expand
A randomized double-blind trial of intravenous immunoglobulin for bullous pemphigoid.
TLDR
IVIG provides a beneficial therapeutic outcome for patients with BP who are resistant to steroid therapy, and changes in the DAS over time, the anti-BP180 antibody titer, and safety for a period of 57days as secondary endpoints. Expand
Methylation and expression analysis of 15 genes and three normally-methylated genes in 13 Ovarian cancer cell lines.
TLDR
It was shown that aberrant methylation and demethylation were frequently observed in ovarian cancer cell lines, and these data will provide a basis for further epigenetic analysis in ovarian cancers. Expand
Silencing of the thrombomodulin gene in human malignant melanoma
TLDR
It is suggested that most human melanomas lack thrombomodulin expression, and that methylation of the promoter CpG island is one of the mechanisms responsible. Expand
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