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Six1 controls patterning of the mouse otic vesicle
Six1 is a member of the Six family homeobox genes, which function as components of the Pax-Six-Eya-Dach gene network to control organ development. Six1 is expressed in otic vesicles, nasal epithelia,Expand
Role of Pax‐5 in the regulation of a mid‐hindbrain organizer’s activity
The mes‐metencephalic boundary (isthmus) has been suggested to act as an organizer in the development of the optic tectum. Pax‐5 was cloned as a candidate for regulator of the organizing center.Expand
Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum
Otx2 is expressed in the mesencephalon and prosencephalon, and Gbx2 is expressed in the rhombencephalon around stage 10. Loss-of-function studies of these genes in mice have revealed that Otx2 isExpand
Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis.
We investigated nuclear factors that bind to delta 1-crystallin enhancer core and regulate lens-specific transcription. A nuclear factor delta EF1, which binds to the essential element of the deltaExpand
The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation.
The repressor delta EF1 was discovered by its action on the DC5 fragment of the lens-specific delta 1-crystallin enhancer. C-proximal zinc fingers of delta EF1 were found responsible for binding toExpand
Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors
The underlying transcriptional mechanisms that establish the proper spatial and temporal pattern of gene expression required for specifying neuronal fate are poorly defined. We have characterized howExpand
Roles of Pax-2 in initiation of the chick tectal development.
Transplantation experiments have shown that the mes-metencephalic boundary (isthmus) acts as an organizer for the development of the optic tectum. We have cloned Pax-2 which is expressed in theExpand
Gain- and loss-of-function in chick embryos by electroporation
It remained very difficult to manipulate gene expression in chick embryos until the advent of in ovo electroporation which enabled the induction of both gain-of-function, and recentlyExpand
Introduction of DNA into chick embryos by in ovo electroporation.
Gene transfer by in ovo electroporation has been applied to the study of developmental biology, especially to central nervous system (CNS) development. Plasmids are injected into the neural tube ofExpand
En-2 regulates the expression of the ligands for Eph type tyrosine kinases in chick embryonic tectum
The retinotectal projection map is organized in a precise retinotopic order, so that the temporo-nasal axis of the retina corresponds to the rostro-caudal axis of the tectum. en-1 and en-2,Expand