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Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.
The purpose of this study was to elucidate the mechanistic bases for the reported reduction in the O(2) cost of exercise following short-term dietary nitrate (NO(3)(-)) supplementation. In aExpand
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Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study.
Dietary supplementation with beetroot juice (BR) has been shown to reduce resting blood pressure and the O(2) cost of submaximal exercise and to increase tolerance to high-intensity cycling. WeExpand
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Muscle metabolic responses to exercise above and below the "critical power" assessed using 31P-MRS.
We tested the hypothesis that the asymptote of the hyperbolic relationship between work rate and time to exhaustion during muscular exercise, the "critical power" (CP), represents the highestExpand
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Influence of hyperoxia on muscle metabolic responses and the power–duration relationship during severe‐intensity exercise in humans: a 31P magnetic resonance spectroscopy study
Severe‐intensity constant‐work‐rate exercise results in the attainment of maximal oxygen uptake, but the muscle metabolic milieu at the limit of tolerance (Tlim) for such exercise remains to beExpand
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Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia.
Exercise in hypoxia is associated with reduced muscle oxidative function and impaired exercise tolerance. We hypothesised that dietary nitrate supplementation (which increases plasma [nitrite] andExpand
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Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults.
Dietary nitrate (NO(3)(-)) supplementation has been shown to reduce resting blood pressure and alter the physiological response to exercise in young adults. We investigated whether these effectsExpand
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Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions
Dietary nitrate supplementation, which enhances nitric oxide (NO) bioavailability, has previously been shown to contribute to improved exercise performance by reducing both oxygen cost and energyExpand
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Dietary nitrate improves sprint performance and cognitive function during prolonged intermittent exercise
It is possible that dietary nitrate (NO3−) supplementation may improve both physical and cognitive performance via its influence on blood flow and cellular energetics.PurposeTo investigate theExpand
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Muscle phosphocreatine and pulmonary oxygen uptake kinetics in children at the onset and offset of moderate intensity exercise
To further understand the mechanism(s) explaining the faster pulmonary oxygen uptake $$(p{\dot{V}}\hbox{O}_{2})$$ kinetics found in children compared to adults, this study examined whether the phaseExpand
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An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy
DNA polymerase δ, whose catalytic subunit is encoded by POLD1, is responsible for lagging-strand DNA synthesis during DNA replication. It carries out this synthesis with high fidelity owing to itsExpand
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