J. Fruton

Publications264
h-index41
Citations6,152
Highly Influential Citations84
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Symposia of the Society for Experimental Biology
Methods of Biochemical Analysis
TLDR
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THE PENETRATION OF VESICANT VAPORS INTO HUMAN SKIN
TLDR
A very precise and reproducible micropipetting technique is described for the introduction of the vesicants into the penetration apparatus, and it is suggested that the permeability of the skin to H vapor is not altered during a 30 minute exposure, due to retention on the skin surface of an appreciable quantity of benzyl-H.
A History Of Pepsin And Related Enzymes
  • J. Fruton
  • Biology
    The Quarterly Review of Biology
  • 1 June 2002
TLDR
After 1975, the three‐dimensional structures of pepsin and many of its relatives were determined by means of x‐ray diffraction techniques, greatly extending insight into the mechanism of the catalytic action of these enzymes.
The Collected Papers of Paul Ehrlich
  • J. Fruton
  • History
    The Yale Journal of Biology and Medicine
  • 1 June 1957
Some Reactions of N-Ethylmaleimide1
Studies on the specificity of pepsin.
A NEW TYPE OF ENZYME IN THE INTESTINAL TRACT.
The mechanism of the catalytic action of pepsin and related acid proteinases.
  • J. Fruton
  • Chemistry
    Advances in enzymology and related areas of…
  • 22 November 2006
The comparative specificity of acid proteinases.
TLDR
The specificity of proteinases operating by a similar catalytic mechanism cannot be explained solely in terms of the amino acid residues flanking the sensitive peptide bond; in addition, the specificity includes significant contributions from secondary interactions arising from complementary relations between parts of the substrate and of the enzyme at a distance from the catalytic site.
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