5-androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression.
- D. Stickney, C. Dowding, J. Frincke
- Medicine, BiologyInternational Immunopharmacology
- 1 April 2007
Antimicrobial metabolites of the sponge Reniera sp
- J. Frincke, D. Faulkner
- Engineering
- 20 April 1982
Antibodies against metal chelates
- D. Reardan, C. Meares, J. Frincke
- BiologyNature
- 18 July 1985
These antibodies show a remarkable preference for indium chelates; changing to another metal such as scandium or gallium can decrease the antibody-binding constant by more than three orders of magnitude, which introduces a new degree of control over the biological distributions of chelated radionuclides.
Radioimmunodetection of melanoma utilizing In-111 96.5 monoclonal antibody: a preliminary report.
- S. Halpern, R. Dillman, J. Frincke
- MedicineRadiology
- 1 May 1985
The 96.5 In-111 MoAb appears to have utility for the detection of metastatic melanoma and is often better seen with single photon emission computed tomography than with planar imaging techniques.
Bifunctional antibody: a binary radiopharmaceutical delivery system for imaging colorectal carcinoma.
- D. Stickney, L. D. Anderson, J. Frincke
- BiologyCancer Research
- 15 December 1991
A unique monoclonal antibody-based drug delivery system, a bifunctional antibody designed to deliver imaging or therapeutic agents, such as radioisotopes, drugs, or biologics, to tumor cells, while minimizing the dose to normal tissue.
Differential cellular catabolism of 111In, 90Y and 125I radiolabeled T101 anti-CD5 monoclonal antibody.
- Y. Naruki, J. Carrasquillo, S. Larson
- BiologyInternational Journal of Radiation Applications…
- 1990
Phase I study of the pharmacokinetics of a radioimmunoconjugate, 90Y-T101, in patients with CD5-expressing leukemia and lymphoma.
- F. Foss, A. Raubitscheck, J. Carrasquillo
- Medicine, BiologyClinical Cancer Research
- 1 November 1998
Ten patients with advanced or refractory CD5-expressing hematologic neoplasms were treated in a Phase I study with the radioimmunoconjugate 90Y-T101, which targets CD5+ lymphocytes, and rapid antigenic modulation of CD5 on circulating T and B cells was observed.
5-androstenediol stimulates multilineage hematopoiesis in rhesus monkeys with radiation-induced myelosuppression.
- D. Stickney, C. Dowding, J. Frincke
- Medicine, BiologyInternational Immunopharmacology
- 1 November 2006
Tumor size: effect on monoclonal antibody uptake in tumor models.
- P. Hagan, S. Halpern, G. David
- Biology, MedicineJournal of Nuclear Medicine
- 1 March 1986
There is strong evidence for a decrease in per g uptake of labeled tumor specific antibodies as tumors increase in size.
In vivo kinetics of radiolabeled monoclonal anti-CEA antibodies in animal models.
- P. Hagan, S. Halpern, D. Carlo
- Biology, MedicineJournal of Nuclear Medicine
- 1 December 1985
Circulating CEA induced the removal of 125I and 111In MoAbs from the vascular compartment and results in decreased tumor uptake of the labeled MoAb, which may account for the relatively low liver activity observed in radioimmunoimaging with intact radioiodinated anti-CEA MoAbs.
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