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The Changing Epidemiology of Clostridium difficile Infections
TLDR
The evidence for the changing epidemiology, clinical virulence and outcome of treatment of CDI is reviewed, and the similarities and differences between data from various countries and continents are reviewed.
Emergence of reduced susceptibility to metronidazole in Clostridium difficile.
TLDR
The emergence of reduced susceptibility to metronidazole is demonstrated in 24.4% of the recent C. difficile ribotype 001 isolates from the authors' institution, which could have implications in the clinical setting due to the poor penetration of metronIDazole into the colon.
Efficacy of Hospital Cleaning Agents and Germicides Against Epidemic Clostridium difficile Strains
TLDR
Differences in the activity of cleaning agents and germicides against C. difficile spores are highlighted and the potential for some of these products to promote sporulation is highlighted.
Models for the study of Clostridium difficile infection
TLDR
Experiments using models have major advantages over clinical studies and have been indispensible in furthering C. difficile research, so it is important for future study programs to carefully consider the approach to use to inform the design and interpretation of clinical studies.
Reduced susceptibility of Clostridium difficile to metronidazole.
Sir, We report the first UK isolate of Clostridium difficile with reduced susceptibility to metronidazole in vitro. The isolate was recovered from the environment of a care for the elderly ward in
Effects of cefotaxime and desacetylcefotaxime upon Clostridium difficile proliferation and toxin production in a triple-stage chemostat model of the human gut.
TLDR
A triple-stage chemostat model of the human gut is used to investigate the behaviour of C. difficile and components of the normal gut flora, in response to exposure to CTX alone, and in combination with its active metabolite desacetylcefotaxime (dCTX).
Role of cephalosporins in the era of Clostridium difficile infection
TLDR
Prescription of multiple antibiotics and a long duration of treatment are key risk factors for CDI, and risk also differs across patient populations, so all of these are taken into account when selecting an antibiotic, rather than focusing on the exclusion of individual drug classes.
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