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A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
Four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer were identified and confirmed in 1,776 affected individuals and 2,072 controls from three additional studies. Expand
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
It is reported that interleukin-1 gene cluster polymorphisms suspected of enhancing production of interleucine-1-beta are associated with an increased risk of both hypochlorhydria induced by H. pylori and gastric cancer. Expand
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
Germ line p53 mutations have been detected in all five LFS families analyzed and can now be examined in additional families with LFS, and in other cancer patients and families with clinical features that might be attributed to the mutation. Expand
Rising incidence of adenocarcinoma of the esophagus and gastric cardia.
Cancer incidence data from nine areas of the United States revealed steadily rising rates from 1976 to 1987 of adenocarcinomas of the esophagus and gastric cardia, which disproportionately affected white men and rarely occurred among women. Expand
Smoking and drinking in relation to oral and pharyngeal cancer.
Risks of oropharyngeal cancer tended to combine more in a multiplicative than additive fashion and were increased more than 35-fold among those who consumed two or more packs of cigarettes and more than four alcoholic drinks/day. Expand
Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.
A proinflammatory cytokine genetic profile increases the risk of noncardia gastric adenocarcinoma but not other upper gastrointestinal cancers, possibly by inducing a hypochlorhydric and atrophic response to gastric H. pylori infection. Expand
A cancer family syndrome in twenty-four kindreds.
The diversity of tumor types in this syndrome suggests pathogenetic mechanisms which differ from hereditary cancers arising in single organs or tissues and laboratory markers are needed to identify high-risk individuals and families and to provide insights into susceptibility mechanisms that may be shared by a wide variety of cancers. Expand
Rising incidence of renal cell cancer in the United States.
Increasing detection of presymptomatic tumors by imaging procedures, such as ultrasonography, computed tomography, and magnetic resonance imaging, does not fully explain the upward incidence trends of renal cell carcinoma. Expand
Changing patterns in the incidence of esophageal and gastric carcinoma in the United States
The authors update the incidence trends through 1994 and further consider the trends by age group. Expand
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295. Expand