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Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype.
- J. Frasor, Jeanne M Danes, B. Komm, K. N. Chang, C. Lyttle, B. Katzenellenbogen
- Medicine, Biology
- 1 October 2003
Estrogens are known to regulate the proliferation of breast cancer cells and to alter their cytoarchitectural and phenotypic properties, but the gene networks and pathways by which estrogenic… Expand
Selective Estrogen Receptor Modulators
- J. Frasor, F. Stossi, Jeanne M Danes, B. Komm, C. Lyttle, B. Katzenellenbogen
- Cancer Research
- 15 February 2004
Selective estrogen receptor modulators (SERMs) such as tamoxifen are effective in the treatment of many estrogen receptor-positive breast cancers and have also proven to be effective in the… Expand
Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome.
The beneficial effect of the selective estrogen receptor (ER) modulator tamoxifen in the treatment and prevention of breast cancer is assumed to be through its ability to antagonize the stimulatory… Expand
Impact of Estrogen Receptor β on Gene Networks Regulated by Estrogen Receptor α in Breast Cancer Cells
Two subtypes of the estrogen receptor (ER), ERα and ERβ, mediate the actions of estrogens, and although 70% of human breast cancers express ERβ along with ERα, little is known about the possible… Expand
Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells.
Two subtypes of the estrogen receptor (ER), ERalpha and ERbeta, mediate the actions of estrogens, and although 70% of human breast cancers express ERbeta along with ERalpha, little is known about the… Expand
Response-Specific and Ligand Dose-Dependent Modulation of Estrogen Receptor (ER) α Activity by ERβ in the Uterus
- J. Frasor, D. H. Barnett, Jeanne M Danes, R. E. Hess, A. Parlow, B. Katzenellenbogen
- 1 July 2003
Estrogen is of great importance in the regulation of uterine function. The aim of this study was to examine the individual physiological roles of each of the two receptors for estradiol, estrogen… Expand
Minireview: Inflammation: an instigator of more aggressive estrogen receptor (ER) positive breast cancers.
Approximately 75% of breast tumors express the estrogen receptor (ER), and women with these tumors will receive endocrine therapy. Unfortunately, up to 50% of these patients will fail ER-targeted… Expand
Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer.
Estrogen receptors (ER) and nuclear factor-kappaB (NF-kappaB) are known to play important roles in breast cancer, but these factors are generally thought to repress each other's activity. However, we… Expand
Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors.
- F. Stossi, D. H. Barnett, J. Frasor, B. Komm, C. Lyttle, B. Katzenellenbogen
- Medicine, Biology
- 1 July 2004
Estrogens exert many important effects in bone, a tissue that contains both estrogen receptors alpha and beta (ERalpha and ERbeta). To compare the actions of these receptors, we generated U2OS human… Expand
Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes.
- J. Frasor, Jeanne M Danes, Cory C. Funk, B. Katzenellenbogen
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 13 September 2005
The nuclear receptor corepressor N-CoR plays a crucial role in the repressive activity of diverse transcription factors, yet little is known about what regulates its cellular level. We have found… Expand