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Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak
It is demonstrated how cryptic same-sex reproduction can enable expansion of a human pathogen to a new geographical niche and contribute to the ongoing production of infectious spores.
The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans
Comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes, and the genome is rich in transposons, many of which cluster at candidate centromeric regions.
Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.
- K. Kwon-Chung, J. Fraser, Y. Bahn
- Biology, MedicineCold Spring Harbor perspectives in medicine
- 1 July 2014
Topics focused on in this article include species description, pathogenesis, life cycle, capsule, and stress response, which serve to highlight the specializations in virulence that have occurred in this unique encapsulated melanin-forming yeast that causes global deaths estimated at more than 600,000 annually.
Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms
Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen Cryptococcus revealed sequential evolutionary events that fashioned this large, highly unusual region, illustrating convergent evolution in sex-determining structures in the animal and fungal kingdoms.
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation
The spectrum of mutations identified provides insights into the genetics underlying the micro-evolution of a laboratory strain, and identifies mutations involved in stress responses, mating efficiency, and virulence.
Recapitulation of the Sexual Cycle of the Primary Fungal Pathogen Cryptococcus neoformans var. gattii: Implications for an Outbreak on Vancouver Island, Canada
A large-scale analysis of the mating abilities of serotype B and C isolates from diverse sources is reported and the CRG1 gene encoding the GTPase-activating protein involved in attenuating pheromone response is disrupted, dramatically increased mating efficiency and enabled mating with otherwise sterile isolates.
Mating-Type Locus of Cryptococcus neoformans: a Step in the Evolution of Sex Chromosomes
This study establishes a new paradigm for mating-type loci in fungi with implications for the evolution of cell identity and self/nonself recognition, and identifies the C. neoformans mating- type locus, which is unique, spans >100 kb, and contains more than 20 genes.
Deciphering the Model Pathogenic Fungus Cryptococcus Neoformans
- A. Idnurm, Y. Bahn, Kirsten Nielsen, Xiaorong Lin, J. Fraser, J. Heitman
- BiologyNature Reviews Microbiology
- 1 October 2005
The biology of C. neoformans is discussed in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.
Nuclear Accumulation of the GATA Factor AreA in Response to Complete Nitrogen Starvation by Regulation of Nuclear Export
- R. Todd, J. Fraser, K. H. Wong, Meryl A. Davis, M. Hynes
- Environmental Science, BiologyEukaryotic Cell
- 1 October 2005
It is concluded that sensing mechanisms discriminate between starvation and the presence of potential nutrients that can signal to the AreA transcription factor, providing a rapid response to changes in the supply of nutrients.
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
It is shown that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibitingNLRP3 activation and inflammasome formation.