J. Fraser

Publications152
h-index44
Citations6,894
Highly Influential Citations345
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Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak
TLDR
It is demonstrated how cryptic same-sex reproduction can enable expansion of a human pathogen to a new geographical niche and contribute to the ongoing production of infectious spores.
View on Nature
The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans
TLDR
Comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes, and the genome is rich in transposons, many of which cluster at candidate centromeric regions.
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Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.
TLDR
Topics focused on in this article include species description, pathogenesis, life cycle, capsule, and stress response, which serve to highlight the specializations in virulence that have occurred in this unique encapsulated melanin-forming yeast that causes global deaths estimated at more than 600,000 annually.
View on PubMed
Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms
TLDR
Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen Cryptococcus revealed sequential evolutionary events that fashioned this large, highly unusual region, illustrating convergent evolution in sex-determining structures in the animal and fungal kingdoms.
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Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation
TLDR
The spectrum of mutations identified provides insights into the genetics underlying the micro-evolution of a laboratory strain, and identifies mutations involved in stress responses, mating efficiency, and virulence.
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Recapitulation of the Sexual Cycle of the Primary Fungal Pathogen Cryptococcus neoformans var. gattii: Implications for an Outbreak on Vancouver Island, Canada
TLDR
A large-scale analysis of the mating abilities of serotype B and C isolates from diverse sources is reported and the CRG1 gene encoding the GTPase-activating protein involved in attenuating pheromone response is disrupted, dramatically increased mating efficiency and enabled mating with otherwise sterile isolates.
View on ASMUSA
Mating-Type Locus of Cryptococcus neoformans: a Step in the Evolution of Sex Chromosomes
TLDR
This study establishes a new paradigm for mating-type loci in fungi with implications for the evolution of cell identity and self/nonself recognition, and identifies the C. neoformans mating- type locus, which is unique, spans >100 kb, and contains more than 20 genes.
View on ASMUSA
Deciphering the Model Pathogenic Fungus Cryptococcus Neoformans
TLDR
The biology of C. neoformans is discussed in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.
View on Nature
Nuclear Accumulation of the GATA Factor AreA in Response to Complete Nitrogen Starvation by Regulation of Nuclear Export
TLDR
It is concluded that sensing mechanisms discriminate between starvation and the presence of potential nutrients that can signal to the AreA transcription factor, providing a rapid response to changes in the supply of nutrients.
View on ASMUSA
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
TLDR
It is shown that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibitingNLRP3 activation and inflammasome formation.
View on Springer
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