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Anal sphincter dysfunction in Parkinson's disease.
TLDR
Dysfunction of the striated anal sphincter musculature may be a significant cause of constipation in some parkinsonian patients, occurring as part of the generalized extrapyramidal motor disorder.
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Comparison of motor response to apomorphine and levodopa in Parkinson's disease.
TLDR
Clinical observations support the notion that integrity of striatal post-synaptic dopamine receptors is a key determinant of responsiveness to dopaminergic treatment in Parkinson's disease.
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Motor response to levodopa in patients with parkinsonian motor fluctuations: a follow-up study over three years.
TLDR
A short response time to the levodopa test dose was not an invariable finding in patients with severe fluctuations, whereas all had large response amplitudes and high "off" phase disability scores.
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Subcutaneous apomorphine in the treatment of Parkinson's disease.
TLDR
Subcutaneous apomorphine is proposed as an effective treatment for patients with incapacitating "off" period disabilities refractory to oral medication and should be considered before experimental implantation procedures.
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Levodopa peripheral pharmacokinetics and duration of motor response in Parkinson's disease.
TLDR
It is proposed that the duration of response is primarily determined by levodopa peripheral pharmacokinetics rather than by central pharmacodynamic factors associated with dopamine storage capacity.
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ROLE OF SUBCUTANEOUS APOMORPHINE IN PARKINSONIAN VOIDING DYSFUNCTION
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A double-blind, controlled study of high-dose L-deprenyl in the treatment of Parkinson's disease.
TLDR
Patients with Parkinson's disease on treatment with L-dopa who showed evidence of wearing-off effects or motor oscillation were studied in a double-blind, placebo-controlled, crossover trial to compare conventional doses of deprenyl with higher doses (up to 40 mg/day) and placebo.
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Anti-Yo antibody-positive cerebellar degeneration associated with endometrial carcinoma: case report and review of the literature.
TLDR
A patient in whom anti-Yo antibody-positive PCD was associated with endometrial carcinoma is presented and an extensive review of the literature outlining the clinical features, pathogenesis and treatment of PCD is presented.
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The effects of oral protein on the absorption of intraduodenal levodopa and motor performance.
TLDR
Findings suggest that competition for levodopa carrier mediated transport by amino acids, is more important at the blood-brain barrier than across the gut mucosa; thereby possibly limiting the efficacy of long-term direct intraduodenal administration of levodOPA.
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Intranasal apomorphine: a new treatment in Parkinson's disease.
TLDR
The initial downward gaze palsy indicates a bilateral involvement of the upper mesencephalon, which can be compared to Wernicke's encephalopathy where hypothermia may occur, and where the mesodiencephalic lesions, although more extended rostro-caudally, are bilateral.
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