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Connecting TNF-α Signaling Pathways to iNOS Expression in a Mouse Model of Alzheimer's Disease: Relevance for the Behavioral and Synaptic Deficits Induced by Amyloid β Protein
Increased brain deposition of amyloid β protein (Aβ) and cognitive deficits are classical signals of Alzheimer's disease (AD) that have been highly associated with inflammatory alterations. TheExpand
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Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain.
During the perinatal period, the central nervous system (CNS) is extremely sensitive to metals, including methylmercury (MeHg). Although the mechanism(s) associated with MeHg-induced developmentalExpand
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Antioxidant status and stress proteins in the gills of the brown mussel Perna perna exposed to zinc.
Zinc, at low levels, has several basic housekeeping functions in metalloenzymes, transcription factors, immunoregulation, growth, and cytoprotection, displaying antioxidant, anti-apoptotic, andExpand
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Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase.
In this study, we investigated the involvement of glutathione peroxidase-GPx in methylmercury (MeHg)-induced toxicity using three models: (a) in mouse brain after treatment with MeHg (40 mg/L inExpand
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Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin.
Plants of the genus Polygala have been shown to possess protective effects against neuronal death and cognitive impairments in neurodegenerative disorders related to excitotoxicity. Moreover,Expand
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Zinc attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain.
Malathion is an organophosphate widely used as an insecticide in agriculture and in public health programs, causing risk to human health. As was recently reported, malathion induces depressant-likeExpand
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Diphenyl diselenide confers neuroprotection against hydrogen peroxide toxicity in hippocampal slices
The present study aimed at investigating the potential in vitro protective effect of the organochalcogenide diphenyl diselenide - (PhSe)2 - against hydrogen peroxide (H2O2)-induced toxicity in ratExpand
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Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb.
We evaluated an alternative method to investigate a possible involvement of environmental toxins in the pathology of Parkinson's disease (PD). There is considerable evidence supporting the role ofExpand
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Cerebellar thiol status and motor deficit after lactational exposure to methylmercury.
This study examined the exclusive contribution of methylmercury (MeHg) exposure through maternal milk on biochemical parameters related to the thiol status (glutathione (GSH) levels, glutathioneExpand
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Antioxidant effect of diphenyl diselenide against sodium nitroprusside (SNP) induced lipid peroxidation in human platelets and erythrocyte membranes: an in vitro evaluation.
An in vitro evaluation on the antioxidant effect of diphenyl diselenide (PhSe)(2), an organochalcogenide, against sodium nitroprusside (SNP)-induced lipid peroxidation (LPO) was conduced. HumanExpand
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