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Diastolic, systolic and sarcoplasmic reticulum [Ca2+] during inotropic interventions in isolated rat myocytes.
TLDR
Results are consistent with a change of diastolic Ca2+i leading to an increase in theCa2+ content of the SR, and hence an increase of the size of the Ca2-i transient during changes in stimulation rate and Ca2 +o. Expand
Contraction and intracellular Ca2+, Na+, and H+ during acidosis in rat ventricular myocytes.
TLDR
It is concluded that a major cause of the initial decline of the twitch during acidosis is a decrease in the response of the contractile proteins to Ca2+ due to the decrease of intracellular pH activating the Na(+)-H+ exchange mechanism. Expand
Pregabalin: in the treatment of generalised anxiety disorder.
TLDR
Oral pregabalin, typically at dosages of 300-600 mg/day, was superior to placebo and similar to lorazepam, alprazolam and venlafaxine in improving anxiety and depressive symptoms in patients with moderate-to-severe generalised anxiety disorder (GAD). Expand
Ca2+ and Na+ in rat myocytes showing different force-frequency relationships.
TLDR
Data from single myocytes isolated from the ventricles of rat hearts are consistent with the hypothesis that the final contractile response observed during changes of stimulation frequency may be dependent on how the Ca2+ loading of the preparation varies with stimulation frequency. Expand
Ceftaroline Fosamil: A Review of its Use in the Treatment of Complicated Skin and Soft Tissue Infections and Community-Acquired Pneumonia
TLDR
Ceftaroline fosamil was generally well tolerated in these trials, with an adverse event profile similar to that of other cephalosporins, and represents an attractive option for the initial empirical treatment of patients hospitalized with cSSTIs or CAP who require intravenous antimicrobial therapy. Expand
Filgrastim. A review of its pharmacological properties and therapeutic efficacy in neutropenia.
TLDR
Prophylactic administration of filgrastim 230 micrograms/m2/day significantly reduces the incidence, duration and severity of neutropenia in patients with previously untreated small-cell lung cancer receiving standard-dose chemotherapy with CDE (cyclophosphamide, doxorubicin plus etoposide). Expand
Crizotinib: A Review of Its Use in the Treatment of Anaplastic Lymphoma Kinase-Positive, Advanced Non-Small Cell Lung Cancer
TLDR
Those treated with crizotinib experienced significant improvements in progression-free survival, objective response rate, lung cancer symptoms and global quality of life, as compared with those treated with standard second-line chemotherapy. Expand
Nicorandil. A review of its pharmacology and therapeutic efficacy in angina pectoris.
TLDR
Clinical experience thus far indicates that nicorandil, with its novel combination of two distinct vasodilator mechanisms, offers an effective alternative to established vasodILator therapy with conventional nitrates and calcium antagonists in the long term treatment of stable angina pectoris. Expand
Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder
TLDR
Pregabalin (Lyrica®), a well established anxiolytic agent, has been approved in the EU for the treatment of generalized anxiety disorder (GAD) in adults and is considered a first-line agent for the long-term treatment of GAD by the World Federation of Societies of Biological Psychiatry. Expand
The effect of a calmodulin inhibitor on intracellular [Ca2+] and contraction in isolated rat ventricular myocytes.
TLDR
There was a decreases in the apparent sensitivity of the contractile proteins to Ca2+ in the presence of W7 which may account, in part, for the decrease in the twitch observed in the present study. Expand
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