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Dendrimers and other dendritic polymers
The author reveals some unique Features of Dendrimers based upon Self--assembly and Host--Guest Properties that have attracted attention in the literature on Dendritic Polymers and their applications in Nanobiological Devices.
Designing dendrimers for biological applications
- Cameron C. Lee, J. A. MacKay, J. Fréchet, F. Szoka
- Biology, ChemistryNature Biotechnology
- 1 December 2005
Advances in understanding of the role of molecular weight and architecture on the in vivo behavior of dendrimers, together with recent progress in the design of biodegradable chemistries, has enabled the application of these branched polymers as anti-viral drugs, tissue repair scaffolds, targeted carriers of chemotherapeutics and optical oxygen sensors.
Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications.
- E. Bachelder, T. Beaudette, Kyle E Broaders, Jesse Dashe, J. Fréchet
- Biology, EngineeringJournal of the American Chemical Society
- 17 July 2008
Owing to its ease of preparation, processability, pH-sensitivity, and biocompatibility, this type of modified dextran should find use in numerous drug delivery applications.
Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules
The novel convergent growth approach to topological macromolecules based on dendritic fragments is described. The polyether dendritic fragments are prepared by starting from what will become the…
Continuous rods of macroporous polymer as high-performance liquid chromatography separation media
Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy
- Kyle E Broaders, Joel A. Cohen, T. Beaudette, E. Bachelder, J. Fréchet
- BiologyProceedings of the National Academy of Sciences
- 7 April 2009
Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated…
Polymer-fullerene composite solar cells.
Polymer-based organic photovoltaic systems hold the promise for a cost-effective, lightweight solar energy conversion platform, which could benefit from simple solution processing of the active layer.
A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas
- Cameron C. Lee, E. Gillies, F. Szoka
- Biology, ChemistryProceedings of the National Academy of Sciences
- 7 November 2006
The remarkable antitumor activity of dendrimer–DOX results from the ability of the d endrimer to favorably modulate the pharmacokinetics of attached DOX.
One-step synthesis of hyperbranched dendritic polyesters
In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.
- Y. J. Kwon, E. James, N. Shastri, J. Fréchet
- BiologyProceedings of the National Academy of Sciences…
- 20 December 2005
Antigens were encapsulated in acid-degradable polymeric particle carriers to cascade cytotoxic T lymphocyte activation to target dendritic cells, and the most potent antigen-presenting cells, the particle carriers, were further conjugated with monoclonal antibodies.