J. Fréchet

Publications815
h-index143
Citations75,648
Highly Influential Citations510
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Dendrimers and other dendritic polymers
Contibutors. Series Preface. A Brief Historical Perspective (D.A. Tomalia naad J.M.J. Frecht) B>I Introduction and Progress in the Control of Macromolecular Architecture Introduction to the Dendritic… Expand
Designing dendrimers for biological applications
TLDR
Advances in understanding of the role of molecular weight and architecture on the in vivo behavior of dendrimers, together with recent progress in the design of biodegradable chemistries, has enabled the application of these branched polymers as anti-viral drugs, tissue repair scaffolds, targeted carriers of chemotherapeutics and optical oxygen sensors. Expand
Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications.
TLDR
Owing to its ease of preparation, processability, pH-sensitivity, and biocompatibility, this type of modified dextran should find use in numerous drug delivery applications. Expand
Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules
The novel convergent growth approach to topological macromolecules based on dendritic fragments is described. The polyether dendritic fragments are prepared by starting from what will become the… Expand
Continuous rods of macroporous polymer as high-performance liquid chromatography separation media
Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy
Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated… Expand
In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles.
TLDR
Antigens were encapsulated in acid-degradable polymeric particle carriers to cascade cytotoxic T lymphocyte activation to target dendritic cells, and the most potent antigen-presenting cells, the particle carriers, were further conjugated with monoclonal antibodies. Expand
Polymer—Fullerene Composite Solar Cells.
In vivo studies on the effect of co-encapsulation of CpG DNA and antigen in acid-degradable microparticle vaccines.
TLDR
It is found in an in vivo cytotoxicity assay that the co-encapsulation of ovalbumin, a model antigen, and immunostimulatory agent in the same particle led to superior cytotoxic T lymphocyte activity compared to particles coadministered with adjuvant in an unbound form. Expand
A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas
TLDR
The remarkable antitumor activity of dendrimer–DOX results from the ability of the d endrimer to favorably modulate the pharmacokinetics of attached DOX. Expand
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