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International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.
The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.
In Vitro and in Vivo Pharmacological Characterization of 5-[(R)-2-(5,6-Diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (Indacaterol), a Novel Inhaled β2 Adrenoceptor Agonist…
- C. Battram, S. Charlton, A. Trifilieff
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 May 2006
The preclinical profile of indacaterol suggests that this compound has a superior duration of action compatible with once-daily dosing in human, together with a fast onset of action and an improved cardiovascular safety profile over marketed inhaled β2 adrenoceptor agonists.
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition.
Neuronal 5-HT receptors in the periphery
- J. Fozard
- Biology, ChemistryNeuropharmacology
- 1 December 1984
Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.
Cardiovascular Response to 8-Hydroxy-2-(di-n-Propylamino) Tetralin (8-OH-DPAT) in the Rat: Site of Action and Pharmacological Analysis
- J. Fozard, A. Mir, D. Middlemiss
- Biology, ChemistryJournal of cardiovascular pharmacology
- 1 March 1987
It is established that the cardiovascular response to 8-OH-DPAT in the rat is centrally mediated and point to the putative 5-HT1A receptor as the key site involved.