• Publications
  • Influence
Canine DLA-79 gene: an improved typing method, identification of new alleles and its role in graft rejection and graft-versus-host disease.
TLDR
This study developed an efficient method to type alleles of a divergent MHC gene in dogs and identified two new alleles, but did not find any statistical correlation between DLA-79 allele disparity and graft rejection or graft-versus-host disease, among the authors' transplant dogs.
Proteomic analysis of soft tissue tumor implants treated with a novel polybisphosphonate.
TLDR
Osteodex showed significant treatment efficacy on soft tissue tumor implants and a global view of changes in protein expression profiles following osteodex treatment is provided.
A Phase I/II trial of weekly gemcitabine with celecoxib and thalidomide for patients with advanced pancreatic cancer
4241 Gemcitabine-based combination regimens have been utilized in the treatment of advanced disease with minimal effect on survival. VEGF and COX-2 overexpression in pancreatic tumor tissue suggest
Protein signatures as potential surrogate biomarkers for stratification and prediction of treatment response in chronic myeloid leukemia patients
TLDR
Findings indicate analyses of a panel of protein signatures is capable of objective prediction of molecular response and therapy choice for CML patients at diagnosis as ‘personalized-medicine-model’.
MER-101-03, a multicenter, phase II study to compare MER-101 20mg tablets to intravenous zoledronic acid 4mg in prostate cancer patients.
TLDR
Orazol weekly therapy appears to be as effective as Zometa, based on the biomarkers analyzed, and a rapid decrease for all four biomarkers was seen at seven days, and was sustained throughout the study.
Phase I trial of chir-258 in multiple myeloma.
TLDR
CHIR-258 is a novel inhibitor of RTKs involved in MM growth and proliferation and has been generally well tolerated, and most drug related AEs were CTC grade 1 or 2, including: headache, dysgeusia, fatigue and anorexia.
...
1
2
...