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Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda.
An ethnopharmacological investigation was conducted among the Baka pygmies of Dja biosphere reserve (Cameroon) to collect information on the antimalarial plants used in their daily life, and extracts of H. floribunda showed remarkable inhibitory activity against drug-resistant strains of Plasmodium falciparum. Expand
Trypanocidal and antileishmanial dihydrochelerythrine derivatives from Garcinia lucida.
This is the first trypanocidal and antileishmanial bioguided study of G. lucida, and the activity of the crude extract as well as of the dihydrochelerythrine derivatives are reported for the first time. Expand
Chemical constituents of the ethyl acetate extracts of the stem bark and fruits of Dichrostachys cinerea and the roots of Parkia bicolor
The antibacterial activities of ethyl acetate, methanol and aqueous extracts of the stem bark of Dichrostachys cinerea and the roots of Parkia bicolor have been evaluated. Ethyl acetate extracts haveExpand
Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.
Intraperitoneal administration of 10a at 50 (mg/kg)/day for 4 days caused a promising prolongation of lifespan in T. brucei STIB795-infected mice, implicating oxidative stress in the trypanocidal mode of action of these 1,2-dihydroquinoline derivatives. Expand
Depsipeptides from microorganisms: a new class of antimalarials.
This paper aims to review the recent advances in depsipeptides as potential antimalarial compounds and some are in clinical use or have entered human clinical trials as antibiotic or anticancer agents. Expand
Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.
Computational studies provide a rationale for the antiparasitic order of activity of these analogues and further insight into the role of the substituents at the 3 and 5 positions of the sulfanilamide ring. Expand
Inhibitors of Tubulin Assembly Identified through Screening a Compound Library
Two compounds are identified with greater potency against mammalian tubulin and the more potent antitubulin agent showed promising activity against cancer cell lines in vitro, with IC50 values ranging from 0.18 to 0.73 μm. Expand
In-vivo antimalarial activity of some oxygenated xanthones
This appears to be the first demonstration of the antimalarial activity of some hydroxyxanthones in vivo, using 4-day suppressive assays against Plasmodium berghei ANKA in BALB/c mice. Expand
Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.
Stable solids possessed low nanomolar IC(50) values against Trypanosoma brucei rhodesiense STIB900 in vitro and provided cures in an early treatment acute mouse model of African trypanosomiasis when given ip at 50mg/kg/day for four consecutive days. Expand