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- Publications
- Influence
Inositol trisphosphate receptor Ca2+ release channels.
- J. Foskett, C. White, King-Ho Cheung, D. D. Mak
- Biology, Medicine
- Physiological reviews
- 1 April 2007
The inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release… Expand
Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
- C. Cárdenas, R. Miller, +11 authors J. Foskett
- Biology, Medicine
- Cell
- 23 July 2010
Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells. Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP. Nevertheless, regulation of… Expand
The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R
- Carl White, Chi Li, +4 authors J. Foskett
- Biology, Medicine
- Nature Cell Biology
- 18 September 2005
Members of the Bcl-2 protein family modulate outer mitochondrial membrane permeability to control apoptosis. However, these proteins also localize to the endoplasmic reticulum (ER), the functional… Expand
MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival
- Karthik Mallilankaraman, Patrick Doonan, +11 authors M. Madesh
- Biology, Medicine
- Cell
- 26 October 2012
Mitochondrial Ca(2+) (Ca(2+)(m)) uptake is mediated by an inner membrane Ca(2+) channel called the uniporter. Ca(2+) uptake is driven by the considerable voltage present across the inner membrane… Expand
Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating
- King-Ho Cheung, D. Shineman, +7 authors J. Foskett
- Biology, Medicine
- Neuron
- 26 June 2008
Mutations in presenilins (PS) are the major cause of familial Alzheimer's disease (FAD) and have been associated with calcium (Ca2+) signaling abnormalities. Here, we demonstrate that FAD mutant PS1… Expand
A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk
- U. Dreses-Werringloer, J. Lambert, +18 authors P. Marambaud
- Biology, Medicine
- Cell
- 27 June 2008
Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (Abeta) peptide deposition. Using TissueInfo to screen for genes… Expand
CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes
- Akiyuki Taruno, V. Vingtdeux, +16 authors J. Foskett
- Chemistry, Medicine
- Nature
- 17 January 2013
Recognition of sweet, bitter and umami tastes requires the non-vesicular release from taste bud cells of ATP, which acts as a neurotransmitter to activate afferent neural gustatory pathways. However,… Expand
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction.
- V. Raghuram, D. Mak, J. Foskett
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 30 January 2001
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent protein kinase- and ATP-regulated chloride channel, the activity of which determines the rate of electrolyte and… Expand
Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase.
- K. Hallows, V. Raghuram, B. Kemp, L. Witters, J. Foskett
- Biology, Medicine
- The Journal of clinical investigation
- 15 June 2000
The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-gated Cl(-) channel that regulates other epithelial transport proteins by uncharacterized mechanisms. We employed a yeast… Expand
Inositol 1,4,5-tris-phosphate activation of inositol tris-phosphate receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
- D. D. Mak, S. McBride, J. Foskett
- Biology
- 22 December 1998
Inositol 1,4,5-tris-phosphate (IP3) binding to its receptors (IP3R) in the endoplasmic reticulum (ER) activates Ca2+ release from the ER lumen to the cytoplasm, generating complex cytoplasmic Ca2+… Expand