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Molecular basis for specificity of nuclear import and prediction of nuclear localization.
Structural Biology and Regulation of Protein Import into the Nucleus.
Crystal Structures of Flax Rust Avirulence Proteins AvrL567-A and -D Reveal Details of the Structural Basis for Flax Disease Resistance Specificity[W]
These studies provide some of the first structural information on avirulence proteins that bind directly to the corresponding resistance proteins, allowing an examination of the molecular basis of the interaction with the resistance proteins as a step toward designing new resistance specificities.
Functional and structural properties of mammalian acyl-coenzyme A thioesterases.
Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation
- J. Forwood, Anil Thakur, B. Kobe
- Biology, ChemistryProceedings of the National Academy of Sciences
- 19 June 2007
The results link the molecular and cellular functions of Acot7 and identify the enzyme as a candidate drug target in inflammatory disease.
The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site.
- J. Forwood, A. Brooks, L. Briggs, C. Xiao, D. Jans, S. Vasudevan
- BiologyBiochemical and biophysical research…
- 21 April 1999
The 37-amino-acid linker interdomain of NS5 contains a nuclear localization sequence (NLS) which is capable of targeting b-galactosidase to the nucleus and appears to inhibit NS5 nuclear targeting, probably through a cytoplasmic retention mechanism.
Substrate specificity of protein kinases and computational prediction of substrates.
The C-terminal Nuclear Localization Signal of the Sex-determining Region Y (SRY) High Mobility Group Domain Mediates Nuclear Import through Importin β1*
This study represents the first characterization of the nuclear import pathway for a HMG domain-containing protein and demonstrates for the first time that recognition of SRY by Impβ is of comparable affinity to that with which Impα/β recognizes conventional NLS-containing substrates.
Structural Basis of High‐Affinity Nuclear Localization Signal Interactions with Importin‐α
The study defines an extended set of binding cavities on the importin‐α surface, and expands on recent observations that longer linker sequences are allowed, and that long‐range electrostatic complementarity can contribute to cNLS‐binding affinity.
LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
In vivo, chemotherapy reduced tumour volume, and when combined with an LSD1 inhibitor, abrogated the mesenchymal signature and promoted an innate, M1 macrophage-like tumouricidal immune response.