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Anti-inflammatory and analgesic activity of a water-soluble fraction from shark cartilage.
- J. Fontenele, G. Viana, J. Xavier-Filho, J. W. de-Alencar
- Brazilian journal of medical and biological…
- 1 May 1996
The results suggest that a molecule of a protein nature in shark cartilage is probably responsible for the effects observed, and the anti-inflammatory and analgesic activities of a water-soluble fraction extracted from sharks cartilage were studied. Expand
Doxycycline protects against pilocarpine-induced convulsions in rats, through its antioxidant effect and modulation of brain amino acids
- C. Nogueira, Flávio Maia Damasceno, +4 authors G. Viana
- Medicine, Chemistry
- Pharmacology Biochemistry and Behavior
- 1 June 2011
The antioxidant effect associated with decreased levels of excitatory and increased levels of inhibitory amino acids could explain the neuroprotective effect of doxycycline. Expand
Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx.
- M. A. Ferreira, O. D. Nunes, J. Fontenele, O. Pessoa, T. L. Lemos, G. Viana
- Chemistry, Medicine
- Phytomedicine : international journal of…
Results show that quinone fraction isolated from the heartwood of Auxemma oncocalyx Taub significantly inhibited paw edema induced by carrageenan at the second, third, and fourth hours, and QF was less effective orally. Expand
Protective effects of amburoside A, a phenol glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats.
Results indicate that CCl (4)-induced oxidative damage in hepatic tissues is reversed by AMB treatment, and the protective effect of AMB is probably due to the phenolic nature of this glucoside. Expand
Toxicological Study of the Hydroalcoholic Extract from Amburana cearensis in Rats
The results of the reproduction study showed that there were no toxic effects on pups (1 st generation) after the subchronic HAE administration, and creatinine concentration was decreased around 29% in the female group. Expand
Anti‐inﬂammatory and smooth muscle relaxant activities of the hydroalcoholic extract and chemical constituents from Amburana cearensis A. C. Smith
It was shown that HAE, Coum and FF inhibited the histamine and serotonin‐induced increase of cutaneous vascular permeability in rats and caused signiﬁcant relaxation of the rat vas deferens previously contracted with adrenaline, acetylcholine or barium chloride. Expand
Cloak and dagger: the case for adult onset still disease and hemophagocytic lymphohistiocytosis
It is proposed that MAS, HLH, SoJIA, and AOSD are indeed the same disease, in different clinical presentations that may be classified based on severity and laboratory findings, but with essentially the same physiopathogenesis. Expand
Cytotoxic Activity of Chalcones Isolated from Lonchocarpus Sericeus (Pocr.) Kunth
- G. Cunha, J. Fontenele, +6 authors L. Costa-Lotufo
- Biology, Medicine
- Phytotherapy research : PTR
- 1 February 2003
Results indicated a possible antimitotic activity of L. sericeus crude extract and their major constituents and the isolated compounds, derricin and lonchocarpin showed cytotoxicity against CEM leukaemic cell line. Expand
The analgesic and anti-inflammatory effects of shark cartilage are due to a peptide molecule and are nitric oxide (NO) system dependent.
- J. Fontenele, G. Araújo, J. W. de Alencar, G. Viana
- Chemistry, Medicine
- Biological & pharmaceutical bulletin
- 15 November 1997
The present work shows an antinociceptive and dose-dependent effect of shark cartilage hydrosoluble fraction (HF) on writhing and formalin tests in mice. The effect was not altered by thalidomide, a… Expand
Is fibromyalgia a cardiovascular disease? A comment on Martinez-Lavin's review 'Stress, the stress response system, and fibromyalgia'
A cardiovascular FMS model is proposed, relating cardiovascular and nociception neural modulation as a possible cause of the central sensitization model and support for a cardiovascular model of FMS and related diseases is provided. Expand