J. Folkman

Publications601
h-index169
Citations148,806
Highly Influential Citations3,035
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  • Publications
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Tumor angiogenesis: therapeutic implications.
  • J. Folkman
  • Medicine
  • The New England journal of medicine
  • 18 November 1971
TLDR
This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization. Expand
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
TLDR
The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute. Expand
Angiogenesis in cancer, vascular, rheumatoid and other disease
TLDR
Think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth, which may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all. Expand
Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TLDR
The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both). Expand
Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth
TLDR
This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth. Expand
What is the evidence that tumors are angiogenesis dependent?
  • J. Folkman
  • Medicine
  • Journal of the National Cancer Institute
  • 3 January 1990
Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is… Expand
Angiogenesis: an organizing principle for drug discovery?
  • J. Folkman
  • Medicine
  • Nature reviews. Drug discovery
  • 2007
TLDR
Viewing the process of angiogenesis as an 'organizing principle' in biology, intriguing insights into the molecular mechanisms of seemingly unrelated phenomena might be gained for the clinical use ofAngiogenesis inhibitors and for drug discovery, for optimizing the treatment of cancer, but possibly also for developing therapeutic approaches for various diseases that are otherwise unrelated to each other. Expand
Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy.
TLDR
This work poses a quantitative theory for tumor growth under angiogenic stimulator/inhibitor control that is both explanatory and clinically implementable and reveals the existence of an ultimate limitation to tumor size underAngiogenic control. Expand
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma
TLDR
It is shown that the inhibition of metastases by a primary mouse tumor is mediated, at least in part, by angiostatin, and a corresponding fragment of human plasminogen has similar activity. Expand
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
TLDR
Using a dosing schedule of cyclophosphamide that provided more sustained apoptosis of endothelial cells within the vascular bed of a tumor, it is shown that a chemotherapeutic agent can more effectively control tumor growth in mice, regardless of whether the tumor cells are drug resistant. Expand
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