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Metabolite profiles and the risk of developing diabetes
Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the development ofExpand
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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.
BACKGROUND Common polymorphisms of the transcription factor 7-like 2 gene (TCF7L2) have recently been associated with type 2 diabetes. We examined whether the two most strongly associated variantsExpand
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Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.
The genes for the sulfonylurea receptor (SUR1; encoded by ABCC8) and its associated islet ATP-sensitive potassium channel (Kir6.2; encoded by KCNJ11) are adjacent to one another on human chromosomeExpand
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Variants in MTNR1B influence fasting glucose levels
To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total ofExpand
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Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. WeExpand
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The genetics of type 2 diabetes: what have we learned from GWAS?
Type 2 diabetes mellitus has been at the forefront of human diseases and phenotypes studied by new genetic analyses. Thanks to genome‐wide association studies, we have made substantial progress inExpand
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Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.
Dyslipidemia is an independent risk factor for type 2 diabetes, although exactly which of the many plasma lipids contribute to this remains unclear. We therefore investigated whether lipid profilingExpand
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A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wideExpand
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Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology,Expand
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2-Aminoadipic acid is a biomarker for diabetes risk.
Improvements in metabolite-profiling techniques are providing increased breadth of coverage of the human metabolome and may highlight biomarkers and pathways in common diseases such as diabetes.Expand
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