Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.
- N. Blume, J. Leonard, Z. J. Xu, O. Watanabe, H. Remotti, J. Fishman
- BiologyArchives of Biochemistry and Biophysics
- 15 September 2000
Analysis of sequence similarity and functional data suggest that Cyp2d22 may be the mouse ortholog of human CYP2D6, and observations support the hypothesis that 2D22 mediates a distinct, biologically significant activity in relation to other mouse 2D family members.
Covalent binding of the endogenous estrogen 16 alpha-hydroxyestrone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization.
- G. Swaneck, J. Fishman
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 November 1988
The present results suggest that covalent modification of the ER may be one mechanism of malignant transformation in estrogen target tissues in breast cancer patients and in women at enhanced risk for the disease.
Competition by Estrogens for Catecholamine Receptor Binding In Vitro
- C. Paden, B. McEwen, J. Fishman, L. Snyder, V. Degroff
- Biology, ChemistryJournal of Neurochemistry
- 1 August 1982
The results show that there is specificity of steroid interactions with catecholamine receptors in the brain, both in terms of steroid structure and receptor type.
Metabolism of estradiol fatty acid esters in man.
- R. Hershcopf, H. Bradlow, J. Fishman, G. Swaneck, J. Larner, R. Hochberg
- BiologyJournal of Clinical Endocrinology and Metabolism
- 1 December 1985
Investigating the primary metabolic transformation of E2, namely C-17 oxidation, of two representative fatty acid esters, in five normal subjects and studying the rate of oxidation after injection provides an index of their in vivo hydrolysis and, thus, a measure of their subsequent biological activity as the free hormone concludes that in man, the C- 17 oxidation of both E2-17 beta-arachidonate and E2 more slowly but to a greater extent than the free steroid.
Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells.
- J. Schneider, M. M. Huh, H. Bradlow, J. Fishman
- Biology, ChemistryJournal of Biological Chemistry
- 25 April 1984
Narcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists.
- R. Heilman, E. Hahn, J. Fishman
- ChemistryJournal of Medicinal Chemistry
- 1 March 1975
The majority of the new narcotic antagonists exhibited oral potencies considerably superior to the parent compounds, with 6-methylene derivatives IIa and IIb showing the most impressive increases.
Narcotic antagonists. 1. Isomeric sulfate and acetate esters of naloxone (N-allylnoroxymorphone).
- C. Linder, J. Fishman
- ChemistryJournal of Medicinal Chemistry
- 1 May 1973
Aromatic hydroxylation of estrogens.
- J. Fishman
- Biology, ChemistryAnnual Review of Physiology
- 1983
The nature of these transformations and the biologi cal properties of their polyphenolic products, the catechol estrogens, are reviewed in this chapter.
Increased estrogen-16α-hydroxylase activity in women with breast and endometrial cancer
- J. Fishman, J. Schneider, R. Hershcopf, H. Bradlow
- Medicine
- 1 April 1984
Estradiol 16 alpha-hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus: a possible model for the hormonal etiology of breast cancer in humans.
- H. Bradlow, R. Hershcopf, C. Martucci, J. Fishman
- BiologyProceedings of the National Academy of Sciences…
- 1 September 1985
A close correlation between the two has been demonstrated with 16-hydroxylation being elevated in strains with a high incidence of tumors, and low in strain with a low incidence of cancer, such as C57BL.
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