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Isolation of SPINK6 in Human Skin
TLDR
The findings suggest that SPINK6 plays a role in modulating the activity of KLKs in human skin and might have therapeutic potential when KLK activity is elevated. Expand
Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6
Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-typeExpand
SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation.
Serine protease inhibitors of the Kazal-type 9 (SPINK9) is a keratinocyte-derived cationic peptide that is found most abundantly in the upper layers of the palmar-plantar epidermis. In vitro, theExpand
Drug-induced lysosomal storage of sulphated glycosaminoglycans.
TLDR
Clinical reports on keratopathy and basophilic cytoplasmic inclusions in blood lymphocytes of tilorone-treated patients suggest that this drug side effect may also occur in man, and the following hypothesis is put forward. Expand
Synovial membrane in rheumatoid arthritis: determination of glycosaminoglycans and age-dependent correlations.
TLDR
A diagram is proposed demonstrating the cumulative progression of rheumatoid arthritis in the synovialis as related to the GAG pattern, which combination with morphological data (scars, proliferation, exudation) may help to describe the development of the disease more acurately. Expand
Tilorone-induced lysosomal storage of glycosaminoglycans in cultured corneal fibroblasts: biochemical and physicochemical investigations.
  • J. Fischer
  • Chemistry, Medicine
  • The Biochemical journal
  • 15 November 1995
TLDR
The results support the hypothesis of a specific interaction between tilorone and particular GAGs, rendering these resistant to enzymic degradation. Expand
Tilorone-induced lysosomal lesions: the bisbasic character of the drug is essential for its high potency to cause storage of sulphated glycosaminoglycans.
TLDR
The present results show that the substitution of the planar aromatic ring system with two basic side chains is essential for the high potency of tilorone in inducing lysosomal GAG storage, paralleled by, and presumably causally related to, strong physicochemical interactions with GAGs. Expand
Drug-induced glycosaminoglycan storage: dose-dependent changes in the pattern of accumulated glycosaminoglycans in cultured bovine and human fibroblasts.
  • J. Fischer
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 8 November 1996
TLDR
Evidence is provided that selective dermatan sulfate accumulation is a characteristic feature of drug-induced glycosaminoglycan storage in cultured bovine and human fibroblasts, if these cells are treated with low concentrations, that are likely to reflect the situation in vivo and that additional heparan sulfATE storage is induced in vitro only by treatment with high concentrations that induce nonspecific cellular lesions. Expand
Adrenomedullin 2.0: Adjusting Key Levers for Metabolic Stability.
TLDR
By combination of palmitoylation, lactam-bridging, and Nα-methylation, ADM analogues protected from enzymatic cleavage in human blood were developed and revealed an explicitly elongated half-life of 5 days in comparison to the wild-type in vitro. Expand
Lysosomal storage of sulfated glycosaminoglycans induced by two bis-aminomethyl anthrachinones
TLDR
The present morphological, radiochemical, and biochemical results show that the bis-aminomethyl anthrachinone compounds investigated cause lysosomal storage of GAGs, although with significantly lower potencies than the Bis-aminoethoxy anthrACHinone. Expand
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