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Cannabinoids and Terpenes as Chemotaxonomic markers in Cannabis
- Sytze Elzinga, J. Fischedick, R. Podkolinski, J. Raber
- BiologyPrime Archives in Chemistry
- 20 July 2015
In this paper, we present principal component analysis (PCA) results from a dataset containing 494 cannabis flower samples and 170 concentrate samples analyzed for 31 compounds. A continuum of…
Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes.
Cannabis - from cultivar to chemovar.
The study indicates the usefulness of a PCA approach for chemotaxonomic classification of Cannabis varieties, based on the analysis of 28 major compounds present in these samples, which were able to identify the Cannabis constituents that defined the samples into distinct chemovar groups.
Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines
Activation of antioxidant response element in mouse primary cortical cultures with sesquiterpene lactones isolated from Tanacetum parthenium.
The structure-activity relationship among the SL isolated indicates that the guaianolides were more active and when lacking the endoperoxide functionality less toxic then the germacranolides.
A qualitative and quantitative HPTLC densitometry method for the analysis of cannabinoids in Cannabis sativa L.
- J. Fischedick, R. Glas, A. Hazekamp, R. Verpoorte
- BiologyPhytochemical analysis : PCA
- 1 September 2009
Results have shown that the HPTLC method is reproducible and accurate for the quantification of Delta(9)-THC in cannabis and is also useful for the qualitative screening of the main neutral cannabinoids found in cannabis cultivars.
Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway.
Integrative Approaches for the Identification and Localization of Specialized Metabolites in Tripterygium Roots1[OPEN]
- B. M. Lange, J. Fischedick, Malte F. Lange, N. Srividya, D. Šamec, B. Poirier
- BiologyPlant Physiology
- 18 November 2016
This work employed an approach that involves the searching of multiple, complementary chromatographic and spectroscopic data sets against the Spektraris database to speed up the metabolite identification process and provides first insights into the cell type specificity of metabolite accumulation in Tripterygium.
Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor.
- J. Fischedick, F. van der Kooy, R. Verpoorte
- BiologyChemical & pharmaceutical bulletin
- 1 February 2010
There was no statistically significant difference between CB1 binding of pure Delta(9)-THC compared to cannabis smoke and vapor at an equivalent concentration of Delta( 9-THC).
Biosynthesis of Diterpenoids in Tripterygium Adventitious Root Cultures1[OPEN]
Considering the significant enrichment of diterpenoids in the culture medium, fast-growing adventitious root cultures may hold promise as a sustainable resource for the large-scale production of triptolide.