• Publications
  • Influence
Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American College of Chest Physicians; the American Association for Respiratory
2001;120;375-396 Chest Neil R. MacIntyre Medicine and the American College of Critical Care American Association for Respiratory Care; American College of Chest Physicians; the Collective Task ForceExpand
  • 891
  • 37
  • PDF
Problems with inhaler use: a call for improved clinician and patient education.
Patient education is a critical factor in the use and misuse of medication inhalers. Inhalers represent advanced technology that is considered so easy to use that many patients and clinicians do notExpand
  • 305
  • 12
  • PDF
Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation.
BACKGROUND The effectiveness of aerosol drug delivery during mechanical ventilation is influenced by the patient, ventilator, and nebulizer variables. The impact of nebulizer type, position on theExpand
  • 170
  • 8
  • PDF
Aerosol Deposition in Neonatal Ventilation
Lung deposition of inhaled drugs in ventilated neonates has been studied in models of questionable relevance. With conventional nebulizers, pulmonary deposition has been limited to 1% of the totalExpand
  • 91
  • 7
  • PDF
In vitro comparison of heliox and oxygen in aerosol delivery using pediatric high flow nasal cannula
Drug administration via high flow nasal cannula (HFNC) has been described in pediatrics but the amount of albuterol delivery with an HFNC is not known. The purpose of this study is to quantifyExpand
  • 82
  • 6
  • PDF
Aerosol delivery from a metered-dose inhaler during mechanical ventilation. An in vitro model.
Successful bronchodilator therapy with a metered-dose inhaler (MDI) in intubated, mechanically ventilated patients requires adequate delivery of aerosol to the lower respiratory tract. We determinedExpand
  • 136
  • 5
Aerosol delivery to ventilated infant and pediatric patients.
  • J. Fink
  • Medicine
  • Respiratory care
  • 1 June 2004
Infants have low tidal volume, vital capacity, and functional residual capacity, and short respiratory cycles (low I:E ratio), which result in a low residence time for aerosol particles and, thus,Expand
  • 69
  • 5
  • PDF
Evaluation of aerosol generator devices at 3 locations in humidified and non-humidified circuits during adult mechanical ventilation.
BACKGROUND The position of the jet or ultrasonic nebulizer in the ventilator circuit impacts drug delivery during mechanical ventilation, but has not been extensively explored, and no study hasExpand
  • 112
  • 4
  • PDF
Optimizing aerosol delivery by pressurized metered-dose inhalers.
The modern era of aerosol therapy began with the introduction of the Medihaler Epi in 1956, after a 13-year-old asthmatic told her father, an officer in the Riker company, that asthma medicationsExpand
  • 94
  • 4
  • PDF
Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial
IntroductionProlonged mechanical ventilation has the potential to aggravate or initiate pulmonary inflammation and cause lung damage through fibrin deposition. Heparin may reduce pulmonaryExpand
  • 74
  • 4
  • PDF