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Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: focus on modulation of CNS monoamine neurotransmitter release.
- J. Finberg
- Biology, ChemistryPharmacology & therapeutics
- 1 August 2014
Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug
TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease.
TV3326 and TV3279 protect against ischemia-induced cytotoxicity in PC12 cells and reduce the oedema, deficits in motor function and memory after closed head injury in mice and shows selectivity for brain MAO, even after 2 months of daily administration, with little or no effect on the enzyme in the intestinal tract and liver.
Effect of Long‐Term Treatment with Selective Monoamine Oxidase A and B Inhibitors on Dopamine Release from Rat Striatum In Vivo
DA metabolism was reduced only by clorgyline, whereas neuronal release of DA was enhanced by both MAO‐A andMAO‐B inhibitors on chronic administration, and the enhanced DA release does not appear to be dependent on production of amphetamine‐like metabolites of the inhibitor.
Copper pathology in vulnerable brain regions in Parkinson's disease
The Iron Chelator Desferrioxamine (Desferal) Retards 6‐Hydroxydopamine‐Induced Degeneration of Nigrostriatal Dopamine Neurons
- D. Ben-shachar, G. Eshel, J. Finberg, M. Youdim
- Biology, ChemistryJournal of neurochemistry
- 1 April 1991
The ability of iron chelators to retard dopaminergic neurodegeneration in the substantia nigra may indicate a new therapeutic strategy in the treatment of Parkinson's disease.
Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
The clinical potential of MAO inhibitors together with detailed knowledge of the enzyme's binding site structure should lead to future developments with these drugs.
Possible role for endothelins in penile erection.
New directions in monoamine oxidase A and B selective inhibitors and substrates.
Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats.
- G. Eisenhofer, J. Finberg
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 March 1994
The above results support the preference of NE over E for neuronal pathways of metabolism, but indicate considerably more complex differences in the metabolism of NE and E by extraneuronal O-methylation and deamination.