• Publications
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Determination of tablet strength by the diametral-compression test.
  • J. Fell, J. Newton
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 May 1970
It has been shown that to obtain reproducible results for the strength of tablets prepared at a given compression force, the tablet must break in such a manner that the tensile stress is the major stress. Expand
An in vivo investigation into the suitability of pH dependent polymers for colonic targeting
Abstract The effect of a pH-dependent polymer coating, Eudragit S, on its ability to protect a model drug and control its release from rapidly disintegrating tablets has been examined in vitro.Expand
Floating dosage forms: an in vivo study demonstrating prolonged gastric retention.
The results of this study suggest that, in the fed state, this freeze-dried calcium alginate multiple-unit FDF has potential for sustained drug delivery for either local or systemic purposes. Expand
Targeting drugs to the colon: delivery systems for oral administration.
This review is concerned with the approaches taken to achieve a universal system for delivery of drugs to the colon and the design of such a system requires the identification and exploitation of a unique feature of the colonic environment. Expand
Amoxycillin release from a floating dosage form based on alginates.
Drug release studies showed that beads prepared with the drug in solution provided some sustained release characteristics and that these could be improved by the addition of amylose, and prepared from alginate solutions containing either dissolved or suspended amoxycillin. Expand
An evaluation of pectin as a carrier for drug targeting to the colon
In vitro experiments demonstrated that high methoxy pectin (pectin USP), when applied as a compression coat, proved capable of protecting a core tablet during conditions mimicking mouth-to-colon transit and was susceptible to enzymatic attack. Expand
Computer analysis of the relation between tablet strength and compaction pressure
The load necessary to fracture lactose monohydrate tablets under diametral compression has been determined using an Instron physical testing instrument, so that true tensile failure was obtained inExpand
Pectin/chitosan mixtures as coatings for colon-specific drug delivery: an in vitro evaluation
The ability of a multiple-unit dosage form to reach the colon intact has been investigated, in vitro, using conditions chosen to simulate the pH and times likely to be encountered during transit toExpand
Controlled drug release from coated floating ion exchange resin beads
Ion exchange resin beads can be loaded with bicarbonate and coated with a semipermeable membrane. These beads exhibit prolonged gastric residence due to release of carbon dioxide which is trappedExpand
An investigation of the disintegration of tablets in biorelevant media.
The purpose of the study was to examine the disintegration of tablets in media designed to simulate conditions pertaining in the stomach, and there was a good correlation between the penetration rate of the fluid into the tablet and the disintegrations time. Expand