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Activation of transforming growth factor β by Trypanosoma cruzi
The anti‐inflammatory cytokine, transforming growth factor β (TGFβ), plays an important role in Chagas disease, which is caused by the protozoan parasite Trypanosoma cruzi. In the current study, weExpand
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Insights into the role of genetic alterations in adrenocortical tumorigenesis
Whereas benign adrenocortical tumors are frequent in the population, adrenocortical carcinoma (ACC) is a rare cancer. Significant advances in the understanding of the pathogenesis of sporadic ACCsExpand
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Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion
Several studies indicate that the activity of cruzipain, the main lysosomal cysteine peptidase of Trypanosoma cruzi, contributes to parasite infectivity. In addition, the parasitic invasion processExpand
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Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies.
In utero exposure to nicotine is associated with increased risk of numerous adverse fetal and neonatal outcomes, which suggests that it acts directly to affect placental development and theExpand
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Aberrant GPCR expression is a sufficient genetic event to trigger adrenocortical tumorigenesis
Aberrant expression of G protein-coupled receptors (GPCR) in the adrenal cortex is observed in some cases of ACTH-independent macronodular adrenal hyperplasias and adenomas associated with CushingExpand
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Expression and regulation of melanocortin receptor-5 (MC5-R) in the bovine adrenal cortex
Among the five members of the melanocortin receptor (MC-R) family, MC2 and MC5 are expressed in peripheral tissues. The receptor MC2 (ACTH receptor) almost exclusively expressed in the adrenal cortexExpand
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Antagonism of EG-VEGF Receptors as Targeted Therapy for Choriocarcinoma Progression In Vitro and In Vivo
Purpose: Choriocarcinoma (CC) is the most malignant gestational trophoblastic disease that often develops from complete hydatidiform moles (CHM). Neither the mechanism of CC development nor itsExpand
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Proteins involved on TGF-β pathway are up-regulated during the acute phase of experimental Chagas disease.
Studies developed by our group in the last years have shown the involvement of TGF-β in acute and chronic Chagas heart disease, with elevated plasma levels and activated TGF-β cell signaling pathwayExpand
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Predictive value of transforming growth factor-β1in Chagas disease: towards a biomarker surrogate of clinical outcome.
BACKGROUND Transforming growth factor-β1 (TGF-β1) may be implicated in the development of Chagas heart disease. However, the clinical value of TGF-β1 measurement is yet to be determined. METHODS WeExpand
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