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Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.
BACKGROUND & AIMS The human equilibrative nucleoside transporter (hENT1) protein transports gemcitabine into cells. Small retrospective studies in pancreatic cancer suggest that levels of hENT1… Expand
Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer
Objective The associations between oral diseases and increased risk of pancreatic cancer have been reported in several prospective cohort studies. In this study, we measured variations of salivary… Expand
Pancreatic cystic neoplasms: management and unanswered questions.
Approximately 10% of persons 70 years old or older are now diagnosed with pancreatic cysts, but it is not clear which ones require additional analysis, interventions, or follow-up. Primary care… Expand
Review article: the management of lower gastrointestinal bleeding
Several recent advances have been made in the evaluation and management of acute lower gastrointestinal bleeding. This review focuses on the management of lower gastrointestinal bleeding, especially… Expand
Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer.
BACKGROUND & AIMS Lack of detection technology for early pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. New strategies and biomarkers… Expand
Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer
Purpose: To carry out an integrative profile of human pancreatic ductal adenocarcinoma (PDAC) to identify prognosis-significant genes and their related pathways. Experimental Design: A concordant… Expand
Detection and tumor staging of malignancy in cystic, intraductal, and solid tumors of the pancreas by EUS.
BACKGROUND EUS can provide detailed imaging of pancreatic malignancies and direct fine needle aspiration (FNA) of pancreatic masses. The ability of EUS to detect and stage malignancy in cystic and… Expand
EUS findings in patients with autoimmune pancreatitis.
BACKGROUND Autoimmune pancreatitis is an increasingly recognized benign condition with a presentation similar to pancreatic neoplasia but responds to corticosteroid therapy. Clinical features, ERCP,… Expand
EUS or percutaneously guided intratumoral TNFerade biologic with 5-fluorouracil and radiotherapy for first-line treatment of locally advanced pancreatic cancer: a phase I/II study.
BACKGROUND TNFeradeBiologic (AdGVEGR.TNF.11D) is a replication-deficient adenoviral vector that expresses tumor necrosis factor-α (TNF-α) under the control of the Egr-1 promoter, which is inducible… Expand
Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis.
BACKGROUND Acute colonic obstruction because of malignancy is often a surgical emergency. Surgical decompression with colostomy with or without resection and eventual re-anastomosis is the… Expand