• Publications
  • Influence
In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes.
A systematic in vitro study was carried out to elucidate the enzymes responsible for the metabolism of haloperidol (HAL) using human liver microsomes and recombinant human cytochrome P450 isoenzymes.Expand
  • 62
  • 6
  • PDF
Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxinN-methyl-4-phenylpyridinium (MMP+) towards cultured dopaminergic neuroblastoma cells
Haloperidol has recently been found to be metabolized to its pyridinium ion (HP+). This conversion of haloperidol to HP+ appears to be similar to the activation of the dopaminergicExpand
  • 24
  • 5
Bioavailability of anthocyanins
  • J. Fang
  • Chemistry, Medicine
  • Drug metabolism reviews
  • 27 October 2014
Abstract Anthocyanins are a subgroup of flavonoids responsible for the blue, purple, and red color of many fruits, flowers, and leaves. Consumption of foods rich in anthocyanins has been associatedExpand
  • 94
  • 4
  • PDF
Some anthocyanins could be efficiently absorbed across the gastrointestinal mucosa: extensive presystemic metabolism reduces apparent bioavailability.
  • J. Fang
  • Chemistry, Medicine
  • Journal of agricultural and food chemistry
  • 31 March 2014
Despite the accumulating evidence supporting the health effects of anthocyanins, their plasma concentrations were found to be very low. However, 30 and 56% of cyanidin 3-glucoside (Cy-3-glc) andExpand
  • 53
  • 4
  • PDF
In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine
In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) enzymes responsible for the oxidative metabolism of loxapine to 8‐hydroxyloxapine, 7‐hydroxyloxapine, N‐desmethylloxapineExpand
  • 15
  • 4
  • 20
  • 4
  • 12
  • 2
Effect of l-deprenyl, its structural analogues and some monoamine oxidase inhibitors on dopamine uptake
  • J. Fang, P. Yu
  • Chemistry, Medicine
  • Neuropharmacology
  • 1 June 1994
The effect on dopamine uptake by L-deprenyl, its structural analogues and different types of monoamine oxidase (MAO) inhibitors was investigated. Both direct [3H]dopamine uptake into rat striatalExpand
  • 54
  • 1
Classification of fruits based on anthocyanin types and relevance to their health effects.
  • J. Fang
  • Chemistry, Medicine
  • Nutrition
  • 1 November 2015
Anthocyanins are a group of water-soluble pigments that confer the blue, purple, and red color to many fruits. Anthocyanin-rich fruits can be divided into three groups based on the types of aglyconesExpand
  • 77
  • 1
  • PDF
Determination of metoprolol, and its four metabolites in dog plasma.
Metoprolol and its metabolites alpha-hydroxymetoprolol, O-desmethylmetoprolol, metoprolol acid and deaminated metoprolol were quantified in dog plasma using an isocratic high-performance liquidExpand
  • 43
  • 1