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Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase
TLDR
The expression and characterization of a human EST distinct from other human STs which sulfate estrogens indicates that this ST may be important in both the metabolism of estrogens and in the regulation of their activities. Expand
Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines.
TLDR
Understanding the regulation of ST activity in normal breast cells and normal breast cell lines will improve knowledge of the role of sulfation in breast cancer and provide a model with which to study the mechanism of action of estrogens in mammary cells. Expand
Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.
TLDR
The results suggest that HNF4alpha plays a central role in the control of SULT2A1 transcription and that rifampicin-liganded PXR suppresses SULT 2A1 expression by interfering with H NF4alpha activity. Expand
Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver.
TLDR
Results indicate that a novel cytosolic ST is present in human tissues, which may have an important role in thyroid hormone and xenobiotic metabolism. Expand
Human liver steroid sulphotransferase sulphates bile acids.
TLDR
The above results suggest that a single steroid sulphotransferase with broad specificity encompassing neutral steroids and bile acids exists in human liver. Expand
Human cytosolic sulfotransferase 2B1: Isoform expression, tissue specificity and subcellular localization
TLDR
The substrate specificity, nuclear localization, and tissue localization of SULT2B1b suggest a role in regulating the responsiveness of cells to adrenal androgens via their direct inactivation or by preventing their conversion to more potent androgens and estrogens. Expand
Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain.
TLDR
The cloning and expression of novel cDNAs from human and rat brain, which are structurally related to the SULTs, and the selective localization of the BR-STL message in brain, suggest an important function in the central nervous system. Expand
Developmental Expression of Aryl, Estrogen, and Hydroxysteroid Sulfotransferases in Pre- and Postnatal Human Liver
TLDR
The present analysis suggests that divergent regulatory mechanisms are responsible for the differential patterns of hepatic SULT1A1, Sult1E1, and SULT2A1 immunoreactive protein levels that occur during pre- and postnatal human development, and implicates a major role for sulfotransferase expression in the developing fetus. Expand
Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4α and Pregnane X Receptor
TLDR
The results suggest that HNF4α plays a central role in the control of SULT2A1 transcription and that rifampicin-liganded PXR suppresses SULT 2A1 expression by interfering with H NF4α activity. Expand
Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.
TLDR
The cloning of a human ST which has an important role in the sulphation of steroids and bile acids in human liver and adrenals is described. Expand
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