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Effects on mice of numbers of animals per cage: an 18-month study (preliminary results).
The more densely housed groups showed markedly reduced food consumption, slightly decreased mean body weights, and a smaller variance of body weights; gastritis was more prevalent in the more densely houses groups.
Effects of housing conditions on food intake, body weight and spontaneous lesions in mice. A review of the literature and results of an 18-month study.
The more densely housed groups showed markedly reduced food consumption, slightly decreased mean body weights, and a smaller variance of body weights.
A second peak in uptake of gentamicin by rat kidney after cessation of treatment.
Gentamicin was administered s.c. to rats once daily for 7 days at 5 mg kg-1. At the end of this period renal concentrations of gentamicin declined from day 1 to day 5 postdosing, but showed a second
A carcinogenicity study in mice of a beta-adrenergic antagonist, primidolol; increased total tumour incidence without tissue specificity.
The possibility that the results of the present study could represent either a co-carcinogenic effect of beta-blocking agents or, alternatively, a statistical contingency is discussed.
The toxicology of the schistosomicidal agent oxamniquine
In chronic studies in mice and hamsters with intermittent dosage regimens relevant to likely usage in man, no evidence of carcinogenicity potential was observed at dose levels up to 150 mg/kg; in rats, however, oxamniquine was much more toxic, the female being 8–10 times more sensitive than the male.
The sub-acute toxicology of digoxin in dogs; clinical chemistry and histopathology of heart and kidneys
Seventeen adult Beagle dogs received intravenous digoxin, over periods up to 30 days, at doses intended to induce minimal toxicity. The clinical signs of toxicity and ECG changes were as expected
Dazoxiben, a Prototype Inhibitor of Thromboxane Synthesis, has Little Toxicity in Laboratory Animals
Dazoxiben is well absorbed after oral administration and the generally negative outcome to these toxicity studies suggests that selective inhibitors of thromboxane synthesis may be largely free of adverse effects which might impede their therapeutic or prophylactic use in clinical medicine.
Tioconazole, a new broad-spectrum antifungal agent: preclinical studies related to vaginal candidiasis.
Tioconazole is a new broad-spectrum imidazole antifungal agent with in vitro activity against common yeast pathogens approximately fourfold greater than miconazole. Experimental cream formulations are
Negative results of carcinogenicity bioassay of methyl carbazate in rats: significance for the toxicological evaluation of carbadox.
Methyl carbazate, a metabolite of carbadox in the rat, was administered orally to rats for 2 years and showed no evidence of any treatment-related toxicity or, in particular, of carcinogenicity.
The Preclinical Toxicity of Dazoxiben: A Specific Inhibitor of Thromboxane A2 Synthetase
Dazoxiben (4–2-(1H-imidazol-l-yl)ethoxy benzoic acid) has been shown to be orally active in man and clinical studies are currently in progress, the therapeutic dose being of the order of 2–3 mg/kg, three times per day.