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Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes.
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Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase.
TLDR
T cell lines, generated by non-specific stimulation with PHA and IL-2, may be reproducibly used to identify HIV-1 isolate-invariant epitopes recognized by the CTL of infected individuals.
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Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients
TLDR
The lack of any acute toxicity or adverse effect on viral burden and the increase in CD4 T-cell counts in the first weeks after the infusion suggests that antiviral CTLs of diverse specificities do not play a significant role in CD 4 T- cell decline.
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A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees.
TLDR
The CTL response in seronegative volunteers treated with two vaccination approaches was compared to find out whether HIV-specific CTL may provide protection against de novo viral infection.
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EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice.
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Ex vivo expansion of HIV type 1-specific cytolytic T cells from HIV type 1-seropositive subjects.
TLDR
Developing potent HIV-specific CTL lines from the blood of infected patients without AIDS opportunistic infections by ex vivo culture of nonspecifically stimulated T cell lines with autologous antigen-presenting cells (APCs) preincubated with immunodominant HIV-1 peptides.
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Recognition of a small number of diverse epitopes dominates the cytotoxic T lymphocytes response to HIV type 1 in an infected individual.
TLDR
The dominant HIV-1 CTL epitopes in infected patients were not predictable on the basis of MHC expression and varied widely in an MHC-diverse population.
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Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients.
TLDR
The lack of any acute toxicity or adverse effect on viral burden and the increase in CD4 T-cell counts in the first weeks after the infusion suggests that antiviral CTLs of diverse specificities do not play a significant role in CD 4 T- cell decline.
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A simple method to selectively expand HIV-1 specific cytotoxic T lymphocytes in vitro.
TLDR
In some patients, viral-specific CTL could be detected after HIV-vaccinia selection even though the mitogen stimulated cultures had no demonstrable antiviral CTL activity, so in vitro vaccinia selection might also be useful to generate CTL lines for adoptive immunotherapy.
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CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis.
TLDR
The results suggest that either diminished CD43 expression or incomplete sialylation may render hematopoietic cells more susceptible to T lymphocyte-mediated cytolysis.
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