• Publications
  • Influence
Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes.
TLDR
Overlapping CTL epitopes restricted by multiple MHC Class I elements were identified in 3 relatively conserved regions of gp160 (amino acids 49-68, 591-600 and 844-863). Expand
Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase.
TLDR
T cell lines, generated by non-specific stimulation with PHA and IL-2, may be reproducibly used to identify HIV-1 isolate-invariant epitopes recognized by the CTL of infected individuals. Expand
Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients.
TLDR
The lack of any acute toxicity or adverse effect on viral burden and the increase in CD4 T-cell counts in the first weeks after the infusion suggests that antiviral CTLs of diverse specificities do not play a significant role in CD 4 T- cell decline. Expand
A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees.
TLDR
The CTL response in seronegative volunteers treated with two vaccination approaches was compared to find out whether HIV-specific CTL may provide protection against de novo viral infection. Expand
EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice.
TLDR
Injection of cytotoxic T cell lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing human lymphoproliferative disease. Expand
Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients
TLDR
The lack of any acute toxicity or adverse effect on viral burden and the increase in CD4 T-cell counts in the first weeks after the infusion suggests that antiviral CTLs of diverse specificities do not play a significant role in CD 4 T- cell decline. Expand
Ex vivo expansion of HIV type 1-specific cytolytic T cells from HIV type 1-seropositive subjects.
TLDR
Developing potent HIV-specific CTL lines from the blood of infected patients without AIDS opportunistic infections by ex vivo culture of nonspecifically stimulated T cell lines with autologous antigen-presenting cells (APCs) preincubated with immunodominant HIV-1 peptides. Expand
Recognition of a small number of diverse epitopes dominates the cytotoxic T lymphocytes response to HIV type 1 in an infected individual.
TLDR
The dominant HIV-1 CTL epitopes in infected patients were not predictable on the basis of MHC expression and varied widely in an MHC-diverse population. Expand
A simple method to selectively expand HIV-1 specific cytotoxic T lymphocytes in vitro.
TLDR
In some patients, viral-specific CTL could be detected after HIV-vaccinia selection even though the mitogen stimulated cultures had no demonstrable antiviral CTL activity, so in vitro vaccinia selection might also be useful to generate CTL lines for adoptive immunotherapy. Expand
CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis.
TLDR
The results suggest that either diminished CD43 expression or incomplete sialylation may render hematopoietic cells more susceptible to T lymphocyte-mediated cytolysis. Expand