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Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity.
TLDR
Enhanced acute inflammation and pulmonary injury with delayed bacterial clearance after SWCNT exposure may lead to increased susceptibility to lung infection in exposed populations.
Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine.
TLDR
The mechanisms involved in selective phosphatidylserine oxidation in the plasma membrane during apoptosis and its association with disturbances of phospholipid asymmetry leading to phosphatidsserine externalization and recognition by macrophage receptors are at the center of the discussion.
Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects.
TLDR
Data suggest that the anti-inflammatory and antiapoptotic properties of CO confer potent cytoprotection in a rat model of lung transplantation, which is limited by the high incidence of acute graft rejection.
Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.
TLDR
It is concluded that nutritional antioxidant strategies can be targeted at minimizing etoposide conversion to etopOSide-O(.), thus minimizing the genotoxic effects of the radicals in bone marrow myelogenous progenitor cells, i.e., chemoprevention of etoboside-induced acute myelogeneous leukemia.
Phospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine.
TLDR
It was shown that selective oxidation of phosphatidylserine precedes its translocation from the inside to the outside surface of the plasma membrane during apoptosis, and a model is proposed in which cytochrome c released from mitochondria by oxidative stress binds to phosphatids located at the cytoplasmic surface ofThe plasma membrane and induces its oxidation.
Role of laminin in maintenance of type II pneumocyte morphology and function.
TLDR
The data suggest that short-term culture and study of differentiated type II pneumocytes may require a laminin-rich substratum, and that THM incorporation into type II cell DNA provides an important early and sensitive index of cell-basement membrane interaction and subsequent maintenance of function.
Quantification of oxidative/nitrosative modification of CYS(34) in human serum albumin using a fluorescence-based SDS-PAGE assay.
TLDR
The application of ThioGlo-1 staining and SDS-PAGE quantified the degree of hSA modification in complex human plasma exposed to oxidative or nitrosative stress and revealed that hSA is more sensitive to S modification than other SH-containing plasma proteins.
Aspects of the pentylenetetrazol kindling model of epileptogenesis in the rat
TLDR
It was found that hepatic microsomal P-450 concentrations were unchanged after chronic PTZ treatment, and no significant changes in brain amino acids, including GABA and taurine, two neuroinhibitory amino acids which have been implicated in the regulation of seizure phenomena, were found in PTZ-kindled animals.
Interactions of beta adrenergic antagonists with isolated rat alveolar type II pneumocytes. I. Analysis, characterization and regulation of specific beta adrenergic receptors.
Binding of beta adrenergic receptors (BAR) in membranes of freshly isolated type II pulmonary epithelial cells to the radioligand [125I]iodocyanopindolol was saturable, steresospecific and of high
Redox sensor function of metallothioneins.
In summary, the redox conversions of MT cysteines are likely to be the principal mechanisms for regulation of metal binding and release by this protein. Oxidative and/or nitrosative challenges can
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