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Differential sensitivity of arteriolar alpha 1- and alpha 2-adrenoceptor constriction to metabolic inhibition during rat skeletal muscle contraction.
Intravital microscopy of rat cremaster skeletal muscle was used to examine the effect of increased oxygen demand on adrenergic constriction of arterioles and suggested that release of dilator substances during moderate exercise may preferentially attenuate alpha 2 constriction to produce small arteriolar dilation and increased capillary density. Expand
Wide Genetic Variation in the Native Pial Collateral Circulation is a Major Determinant of Variation in Severity of Stroke
The data show that the extent of the native pial collateral circulation and collateral remodeling after obstruction vary widely with genetic background, and suggest that this variability, due to natural polymorphisms, is a major contributor to variability in infarct volume. Expand
ATP modulates load‐inducible IL‐1β, COX 2, and MMP‐3 gene expression in human tendon cells
It is demonstrated that mechanical loading induces ATP release in tendon cells and stimulates expression of IL‐1β, COX 2, and MMP‐3, and that extracellular ATP might inhibit the load‐inducible gene expression. Expand
In Situ Analysis of α‐Adrenoceptors on Arteriolar and Venular Smooth Muscle in Rat Skeletal Muscle Microcirculation
  • J. Faber
  • Chemistry, Medicine
  • Circulation research
  • 1 January 1988
The data suggest that adrenergic regulation of large arterioles and venules in skeletal muscle uses both α1- and α2-adrenoceptors, and precapillary arteriols, however, may be subserved predominantly byα2-receptors. Expand
Catecholamine-Induced Vascular Wall Growth Is Dependent on Generation of Reactive Oxygen Species
Data demonstrate that the trophic effect of catecholamines on vascular wall cells is dependent on a ROS-sensitive step that the authors hypothesize consists of activation of the NAD(P)H-dependent vascular oxidase. Expand
Hypoxia induces heart regeneration in adult mice
It is demonstrated that the endogenous regenerative properties of the adult mammalian heart can be reactivated by exposure to gradual systemic hypoxaemia, and the potential therapeutic role of hypoxia in regenerative medicine is highlighted. Expand
Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains.
These strains offer a model to investigate genetic determinants of collateral formation and growth in ischemia and suggest a cis-acting polymorphism in the Vegfa gene in BALB/c could contribute to reduced VEGF-A expression and, in turn, the above deficiencies in this strain. Expand
Transactivation of Epidermal Growth Factor Receptor Mediates Catecholamine-Induced Growth of Vascular Smooth Muscle
The data suggest that &agr;1-adrenoceptor–mediated SMC growth requires ROS-dependent shedding of HB-EGF, transactivation of EGFR, and activation of the MEK1/2-dependent MAP kinase pathway, which may link sympathetic activity to arterial wall growth in adaptive remodeling and hypertrophic disease. Expand
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
A summary of the meeting and the resultant discussion of how vascular factors contribute to Alzheimer's disease and related dementia is summarized, including an outline of next steps needed to move this area of research forward. Expand
Differential activation of alpha 1- and alpha 2-adrenoceptors on microvascular smooth muscle during sympathetic nerve stimulation.
The data suggest that for large arterioles, which are known to possess both receptors, alpha 1-adrenoceptors are preferentially stimulated by nerve-released norepinephrine, which may allow neurogenic regulation of these vessel segments to be differentially susceptible to modulation by other extrinsic and intrinsic vasoactive controls. Expand