• Publications
  • Influence
Parental expression of the chromodomain protein Pdd1p is required for completion of programmed DNA elimination and nuclear differentiation.
Thousands of DNA elimination events occur during somatic differentiation of many ciliated protozoa. In Tetrahymena, the eliminated DNA aggregates into submacronuclear structures containing theExpand
  • 103
  • 20
The HP1 chromo shadow domain binds a consensus peptide pentamer
Heterochromatin-associated protein 1 (HP1) is thought to affect chromatin structure through interactions with other proteins in heterochromatin. Chromo domains located near the amino (amino chromo)Expand
  • 253
  • 15
Molecular evidence that the myxozoan protists are metazoans.
The evolutionary origins of the protistan phylum, Myxozoa, have long been questioned. Although these obligate parasites are like protozoans in many features, several aspects of their ontogeny andExpand
  • 211
  • 14
Pdd1p, A Novel Chromodomain-Containing Protein, Links Heterochromatin Assembly and DNA Elimination in Tetrahymena
During Tetrahymena conjugation, programmed DNA degradation occurs in two separate nuclei. Thousands of germline-specific deletion elements are removed from the genome of the developing somaticExpand
  • 167
  • 13
The Hinge and Chromo Shadow Domain Impart Distinct Targeting of HP1-Like Proteins
ABSTRACT Drosophila heterochromatin-associated protein 1 (HP1) is an abundant component of heterochromatin, a highly condensed compartment of the nucleus that comprises a major fraction of complexExpand
  • 153
  • 13
Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location.
Heterochromatin proteins are thought to play key roles in chromatin structure and gene regulation, yet very few genes have been identified that are regulated by these proteins. We performedExpand
  • 182
  • 12
  • PDF
Excision of micronuclear-specific DNA requires parental expression of pdd2p and occurs independently from DNA replication in Tetrahymena thermophila.
Elimination of germ-line DNA segments is an essential step in the somatic development of many organisms and in the terminal differentiation of several specialized cell types. In binuclear ciliates,Expand
  • 62
  • 4
Programmed DNA Degradation and Nucleolar Biogenesis Occur in Distinct Organelles During Macronuclear Development in Tetrahymena
ABSTRACT. Programmed DNA rearrangements, including DNA degradation, characterize the development of the soma from the germline in a number of developmental systems. Pddl p (programmed DNA degradationExpand
  • 26
  • 2
Pdd1p associates with germline-restricted chromatin and a second novel anlagen-enriched protein in developmentally programmed DNA elimination structures.
Programmed DNA rearrangements, including DNA diminution, characterize the differentiation of somatic from germline nuclei in several developmental systems. Pdd1p (Programmed DNA degradation proteinExpand
  • 47
  • 1
  • PDF
An abundant nucleolar phosphoprotein is associated with ribosomal DNA in Tetrahymena macronuclei.
An abundant 52-kDa phosphoprotein was identified and characterized from macronuclei of the ciliated protozoan Tetrahymena thermophila. Immunoblot analyses combined with light and electron microscopicExpand
  • 23
  • 1