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Low-level lead-induced neurotoxicity in children: an update on central nervous system effects
In integrating physiological and clinical data, it may be suggested that the different mechanisms of low level lead neurotoxicity have a final common functional pathway. Expand
Cellular and molecular toxicity of lead in bone.
Compartmental analysis indicates that the kinetic distribution and behavior of intracellular lead in osteoblasts and osteoclasts is similar to several other cell types, suggesting that the toxic effects of lead on bone cell function may be produced by perturbation of the calcium and cAMP messenger systems in these cells. Expand
Reduction in 1,25-dihydroxyvitamin D in children with increased lead absorption.
It is shown that a diet low in calcium increases lead retention and that there are associated biochemical and morphologic manifestations of enhanced lead toxicit... Expand
Relationships among blood lead levels, iron deficiency, and cognitive development in two-year-old children.
Primary analyses suggested that 1) the change in cognitive functioning of iron-deficient children was related to change in hemoglobin, and 2) the decline in blood lead was less in iron- deficient than inIron-sufficient children, which is inversely related to changes in cognition. Expand
The effect of Pb(2+) on the structure and hydroxyapatite binding properties of osteocalcin.
A molecular mechanism of Pb(2+) toxicity where low Pb (2+) levels can inappropriately perturb Ca( 2+) regulated processes is suggested, which could play a role in the observed low bone formation rates and decreased bone density observed in P b(2+)-intoxicated animals. Expand
Cellular lead toxicity and metabolism in primary and clonal osteoblastic bone cells.
Experiments show that primary osteoblastic bone cells and ROS cells exhibit similar steady-state lead kinetics, and intracellular lead distribution, and these data establish a working model of lead Kinetics in osteoblastics bone cells, and now permit an integrated view of leadKinetics in bone. Expand
Osteocalcin in human serum: a circadian rhythm.
This study illustrates the importance of regulating the time of blood sampling for osteocalcin determinations in clinical investigations of metabolic bone disease and found Circadian rhythmicity in circulating osteoccin was found in 9 of the 10 individuals studied. Expand
Absence of seasonal variation in serum concentrations of 1,25-dihydroxyvitamin D despite a rise in 25-hydroxyvitamin D in summer.
Despite a seasonal variation in the precursor of calcitriol, the levels of this most active metabolite of vitamin D do not change in relation to sunlight exposure, further evidence of the tight feedback regulation of calcitriol. Expand
Circadian rhythms of blood minerals in humans.
A computer-derived model curve representing the 24-hour fluctuations in ionized calcium cannot be correlated consistently with curves for total calcium or phosphate. Expand
Management of childhood lead poisoning.