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A SIMPLE SYNTHESIS OF ENAMIDES FROM KETOXIMES
Chemical and enzymic studies on the characterization of intermediates during the removal of the 14alpha-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives.
- M. Akhtar, K. Alexander, R. B. Boar, J. F. Mcghie, D. H. Barton
- Chemistry, Medicine
- The Biochemical journal
- 1 March 1978
By using cell-free preparations of rat liver it was shown that the removal of the 14alpha-methyl group (C-32) of steroids containing either a delta7(8) or a delta8(9) double bond is attended… Expand
The laboratory preparation of p‐aminosalicylic acid from phenyl‐acetic acid
In the course of related preparative work on p-aminosalicylic acid derivatives, it was brought to our notice by certain workers on the bacteriological side that samples of the acid itself, obtained… Expand
An improved synthesis of 13-epi-androstanes and of 13-epi-oestranes
Treatment of a 17-hydroxyimino-steroid with refluxing acetic anhydride and pyridine affords an equilibrium mixture of 13-epi-enimide and 13-epi-enamide. A free-radical mechanism is proposed. Acidic… Expand
874. Aliphatic acids. Part II. Some aliphatic epoxy-acids and related compounds
568. Conformational anomalies in some triterpenoid bromo-ketones
The pathway for the removal of C-32 in cholesterol biosynthesis
It is shown that a Δ8(14)-sterol is not involved in cholesterol biosynthesis; the removal of C-32 in sterols containing a double bond at either Δ7(8) or Δ8(9) is attended exclusively with the… Expand
Isolation and some reactions of lanosterol. A synthesis of agnosterol.
A convenient and efficient method for the isolation of lanosterol from ‘isocholesterol’ is described. Some synthetic potentials of the intermediate dibromides are discussed and are illustrated by an… Expand
Photochemical transformations. Part XXV. The synthesis of cycloartenol
3β-Acetoxy- and 3β-benzoyloxy-lanost-24-en-11β-ol nitrites, readily available from lanosterol, on photolyis in the presence of iodine give 19-iodo-derivatives. By further transformations cycloartenol… Expand
The synthesis of some 32-functionalised lanostane derivatives.
- P. Batten, T. Bentley, R. B. Boar, R. Draper, J. F. Mcghie, D. H. Barton
- Chemistry, Medicine
- Journal of the Chemical Society. Perkin…
Lanosterol has been converted into 3β-acetoxylanost-7-en-32-onitrile and thence into 3β-acetoxylanost-7-en-32-al and 3β,32-diacetoxylanost-7-ene. 3β-Acetoxy-11-oxolanost-8-en-32-onitrile and methyl… Expand