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Docetaxel/Gemcitabine Followed by Gemcitabine and External Beam Radiotherapy in Patients With Pancreatic Adenocarcinoma
TLDR
Docetaxel/gemcitabine followed by gem citabine/radiotherapy is active in the treatment of pancreatic adenocarcinoma, with manageable toxicity.
Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses.
TLDR
In horses with ischemia-injured jejunum, lidocaine administered IV reduced plasma prostaglandin E(2) metabolite concentration and mucosal COX-2 expression and coadministration of lidocane with flunixin ameliorated the flunxin-induced increase in mucosal neutrophil counts.
The effect of nonsteroidal anti-inflammatory drugs on the equine intestine.
TLDR
Experimental evidence suggests that those NSAIDs with cyclooxygenase independent anti-inflammatory effects or a COX-2 selective mode of action may offer significant advantages over traditional NSAIDs.
The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses.
TLDR
It is shown that deracoxib is absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in the dog and horse.
Use of a wireless, inertial sensor-based system to objectively evaluate flexion tests in the horse.
TLDR
Findings support the use of inertial sensor systems to objectively assess response to flexion tests and further investigation is warranted to establish cut-off values for objective assessment of other diagnostic procedures.
Use of large‐scale veterinary data for the investigation of antimicrobial prescribing practices in equine medicine
TLDR
Empirical use of reserved antimicrobials was common in a first-opinion US and Canadian horse cohort, and further advice and guidance should be issued to first- opinion veterinarians to safeguard antimicrobial efficacy.
Proportion of nonsteroidal anti‐inflammatory drug prescription in equine practice
TLDR
Clinical practice can differ between countries although the influence of individual practitioners and practice-specific policy on apparent intercountry differences requires further research.
Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses.
TLDR
Robenacoxib selectively inhibited COX-2 and allowed recovery of barrier function in ischemia-injured equine jejunal tissue in vitro.
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