J. F. Ernst

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Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi.

Volker R. Stoldt, A Sonneborn, Christoph E. Leuker, J. F. Ernst
The EMBO journal
1997

We identified a gene of the fungal pathogen Candida albicans, designated EFG1, whose high-level expression stimulates pseudohyphal morphogenesis in the yeast Saccharomyces cerevisiae. In a central… (More)

APSES proteins regulate morphogenesis and metabolism in Candida albicans.

Thomas Doedt, Shankarling Krishnamurthy, +5 authors J. F. Ernst
Molecular biology of the cell
2004

Fungal APSES proteins regulate morphogenetic processes, including filamentation and differentiation. The human fungal pathogen Candida albicans contains two APSES proteins: the regulator Efg1p and… (More)

Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans.

A Sonneborn, Dirk P Bockmühl, Michaela Gerads, K Kurpanek, Dominique Sanglard, J. F. Ernst
Molecular microbiology
2000

External signals induce the switch from a yeast to a hyphal growth form in the fungal pathogen Candida albicans. We demonstrate here that the catalytic subunit of a protein kinase A (PKA) isoform… (More)

Transcriptional response of Candida albicans to hypoxia: linkage of oxygen sensing and Efg1p-regulatory networks.

Eleonora R Setiadi, Thomas Doedt, Fabien Cottier, Christine Noffz, J. F. Ernst
Journal of molecular biology
2006

The major human fungal pathogen, Candida albicans, colonizes different body sites, differing greatly in oxygen levels. Using whole-genome DNA microarrays, we analysed the transcriptomal response of… (More)

Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans.

Dirk P Bockmühl, Shankarling Krishnamurthy, Michaela Gerads, A Sonneborn, J. F. Ernst
Molecular microbiology
2001

TPK1 and TPK2 encode both isoforms of protein kinase A (PKA) catalytic subunits in Candida albicans. Mutants lacking both TPK1 alleles showed defective hyphal morphogenesis on solid inducing media,… (More)

Transcription factors in Candida albicans - environmental control of morphogenesis.

J. F. Ernst
Microbiology
2000

Awareness of Candida albicans as a major human health threat has risen during recent years. Although infections by C. albicans can be relatively mild and superficial, systemic mycoses often occur in… (More)

PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.

Stephan K-H Prill, Birgit Klinkert, Claudia Timpel, Cheryl A Gale, Klaus Schröppel, J. F. Ernst
Molecular microbiology
2005

Protein O-mannosyltransferases (Pmt proteins) initiate O-mannosylation of secretory proteins. The PMT gene family of the human fungal pathogen Candida albicans consists of PMT1 and PMT6, as well as… (More)

Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator.

A Sonneborn, Bernd Tebarth, J. F. Ernst
Infection and immunity
1999

Phenotypic switching in Candida albicans spontaneously generates different cellular morphologies and is manifested in strain WO-1 by the reversible switching between the white and opaque phenotypes.… (More)

A potential phosphorylation site for an A-type kinase in the Efg1 regulator protein contributes to hyphal morphogenesis of Candida albicans.

Efg1p in the human fungal pathogen Candida albicans is a member of the conserved APSES class of proteins regulating morphogenetic processes in fungi. We have analyzed the importance for hyphal… (More)

Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator.

A Sonneborn, Dirk P Bockmühl, J. F. Ernst
Infection and immunity
1999

Chlamydospore formation of the fungal pathogen Candida albicans was found to depend on the Efg1 protein, which regulates the yeast-hyphal transition. Isogenic mutants lacking EFG1 or encoding T206A… (More)

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