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Factors determining the sequence of oxidative decarboxylation of the 2- and 4-propionate substituents of coproporphyrinogen III by coproporphyrinogen oxidase in rat liver.
The experimental results, together with the recognition that in all known substrates of coproporphyrinogen oxidase only those propionate groups flanked by a specific arrangement of substituents are decarboxylated, indicate that the 4-propionate group ofcoproporphirinogen III cannot be attacked until the 2-propIONate group has been decar boxylated. Expand
Consideration of the probable relative activities of the enzymes of haem biosynthesis in the liver in H.C.C suggests that the acute attacks of porphyria occur when the activity of uroporphyrinogen-I-synthase becomes rate-limiting for haem synthesis. Expand
Effects of Glyphosate on Chloroplast Ultrastructure of Quackgrass Mesophyll Cells
Phytotoxicity of glyphosate (N-(phosphonomethyl) glycine), applied at 0, 0.56, 1.12, 1.68, 2.24 and 4.49 kg ai/ha to uniform, naturally growing quackgrass, [Agropyron repens (L.) Beauv.] plants, wasExpand
Toxicosis from and possible adaptation to Galega officinalis in sheep and the relationship to Verbesina encelioides toxicosis.
Ewes administered the plant on several consecutive days developed an apparent adaptation to the toxin of the plant and were thereby able subsequently to tolerate levels 5-10 times the pre-treatment lethal dose with no discernible adverse clinical or pathological effects. Expand
Individual animal susceptibility and its relationship to induced adaptation or tolerance in sheep to Galega officinalis L.
Oral administration of Galega officinalis L to sheep demonstrated a marked variation in individual animal susceptibility to the toxic effects of the plant. As little as 5 g/kg of dried ground plantExpand
The effect of the porphyrogenic compound, hexachlorobenzene, on the activity of hepatic uroporphyrinogen decarboxylase in the rat.
It is suggested that hexachlorobenzene or a metabolite acts directly to decrease the activity of the enzyme, which is suggested to cause porphyria in female Wistar rats. Expand
Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria.
Preferential rupture of the outer membrane of mitochondria from rat liver releases coproporphyrinogen oxidase in parallel with components of the intermembrane space to allow haem synthesis to be completed. Expand
The affinity of phlorizin-like compounds for a beta-glucosidase in intestinal brush borders: comparison with the glucose transport system.
The affinities of these compounds for the glucose transport system and phlorizin hydrolase were compared and the relative inhibitory potency of all but two of the analogs was the same in either system suggesting that there are similarities in the architecture of the two receptors. Expand
Natural Dermatophilus congolensis infection in camels (Camelus dromedarius) from Kenya.
An outbreak of dermatophilosis was observed in camel calves being reared on a commercial farm in a semi-arid area in Kenya and Histopathology and bacterial isolation were used to diagnose the diseases. Expand