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Macrophages at the Fetal–Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10
- J. Svensson, M. Jenmalm, A. Matussek, R. Geffers, G. Berg, J. Ernerudh
- Biology, Medicine
- The Journal of Immunology
- 1 October 2011
During pregnancy, the maternal immune system is challenged by the presence of the fetus, which must be tolerated despite being semiallogeneic. Uterine mucosal (or decidual) macrophages (Mϕ), one of… Expand
Gene Expression Profiling of Human Decidual Macrophages: Evidence for Immunosuppressive Phenotype
Background Although uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface, their global gene expression profile is not known. Methodology/Principal… Expand
Cytokine mapping of sera from women with preeclampsia and normal pregnancies.
- Yvonne Jonsson, M. Rubér, +5 authors C. Ekerfelt
- Journal of reproductive immunology
- 1 June 2006
INTRODUCTION Preeclampsia is a pregnancy-specific syndrome. The immune system in preeclampsia is changed with an increased innate activity and there is a hypothesis of a shift towards Th1-type… Expand
An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.
- A. Wikby, F. Ferguson, +7 authors B. Johansson
- The journals of gerontology. Series A, Biological…
- 1 May 2005
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment… Expand
Seminal Plasma Proteins: What Role Do They Play?
- H. Rodríguez-Martínez, U. Kvist, J. Ernerudh, L. Sanz, J. Calvete
- Biology, Medicine
- American journal of reproductive immunology
- 1 July 2011
Citation Rodríguez‐Martínez H, Kvist U, Ernerudh J, Sanz L, Calvete JJ. Seminal Plasma Proteins: What Role Do They Play? Am J Reprod Immunol 2011; 66 (Suppl. 1): 11–22
FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1
In pregnancy, the decidua is infiltrated by leukocytes promoting fetal development without causing immunological rejection. Murine regulatory T (Treg) cells are known to be important immune… Expand
No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study
- J. Strindhall, B. Nilsson, S. Löfgren, J. Ernerudh, A. Wikby
- Experimental Gerontology
- 1 August 2007
In the present NONA immune longitudinal study, we investigate the previously identified Immune Risk Profile (IRP), defined by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus… Expand
Detection of spontaneous and antigen-induced human interleukin-4 responses in vitro: comparison of ELISPOT, a novel ELISA and real-time RT-PCR.
- C. Ekerfelt, J. Ernerudh, M. Jenmalm
- Biology, Medicine
- Journal of immunological methods
- 1 February 2002
Interleukin-4 (IL-4) is an important T-helper cell type 2 (Th2) cytokine in man, driving Th2 polarisation and exerting the most antagonistic effects to the Th1 cytokine interferon-gamma (IFN-gamma).… Expand
Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid
- J. Mellergård, M. Edström, M. Vrethem, J. Ernerudh, C. Dahle
- Multiple sclerosis
- 1 February 2010
Natalizumab exerts impressive therapeutic effects in patients with multiple sclerosis (MS). The proposed main mode of action is reducing transmigration of leukocytes into the CNS, but other… Expand
Prevention of recurrent spontaneous abortion by intravenous immunoglobulin: a double-blind placebo-controlled study.
- B. Jablonowska, A. Selbing, M. Palfi, J. Ernerudh, S. Kjellberg, B. Lindton
- Human reproduction
- 1 March 1999
The aim of this study was to evaluate the therapeutic efficacy of intravenous immunoglobulin (IVIG) in the prevention of recurrent spontaneous abortion (RSA). In a double-blind, randomized,… Expand