• Publications
  • Influence
A method to measure the effective spread of focally injected muscimol into the central nervous system with electrophysiology and light microscopy
A method was developed to quantitate the volume of brain inactivated by muscimol focally injected. Tritiated muscimol was injected into the cerebellum and closely spaced sequential microelectrodeExpand
  • 90
  • 20
Collateral Growth and Angiogenesis Around Cortical Stroke
Background and Purpose— We tested the hypothesis that there are significant long-term local vascular changes after ministroke that could form a basis for functional recovery. Methods— A 6- to 8-mmExpand
  • 269
  • 7
Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial.
IMPORTANCE Uveal melanoma is characterized by mutations in GNAQ and GNA11, resulting in mitogen-activated protein kinase pathway activation. OBJECTIVE To assess the efficacy of selumetinib, aExpand
  • 251
  • 6
Cryoablation: mechanism of action and devices.
Cryoablation refers to all methods of destroying tissue by freezing. Cryoablation causes cellular damage, death, and necrosis of tissues by direct mechanisms, which cause cold-induced injury toExpand
  • 138
  • 6
Image-guided thermal ablation of tumors increases the plasma level of interleukin-6 and interleukin-10.
PURPOSE To identify changes in plasma cytokine levels after image-guided thermal ablation of human tumors and to identify the factors that independently predict changes in plasma cytokine levels. Expand
  • 65
  • 6
Postnatal growth of intrinsic connections in mouse barrel cortex
Surprisingly little is known about the development of connections within a functional area of the cerebral cortex. We examined the postnatal growth of connections in mouse barrel cortex during theExpand
  • 43
  • 6
HER kinase inhibition in patients with HER2- and HER3-mutant cancers
Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead toExpand
  • 202
  • 5
Percutaneous Radiofrequency Ablation of Colorectal Cancer Liver Metastases: Factors Affecting Outcomes--A 10-year Experience at a Single Center.
PURPOSE To identify predictors of oncologic outcomes after percutaneous radiofrequency ablation (RFA) of colorectal cancer liver metastases (CLMs) and to describe and evaluate a modified clinicalExpand
  • 129
  • 4
AKT Inhibition in Solid Tumors With AKT1 Mutations.
Purpose AKT1 E17K mutations are oncogenic and occur in many cancers at a low prevalence. We performed a multihistology basket study of AZD5363, an ATP-competitive pan-AKT kinase inhibitor, toExpand
  • 94
  • 4
Randomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone.
PURPOSE Transarterial chemoembolization is accepted therapy for hepatocellular carcinoma (HCC). No randomized trial has demonstrated superiority of chemoembolization compared with embolization, andExpand
  • 164
  • 3