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Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion.
The synthetic peptides DP-107 and DP-178 (T-20), derived from separate domains within the human immunodeficiency virus type 1 (HIV-1) transmembrane (TM) protein, gp4l, are stable and potentExpand
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Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer.
The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore aExpand
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Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.
A two-fold (C2) symmetric inhibitor of the protease of human immunodeficiency virus type-1 (HIV-1) has been designed on the basis of the three-dimensional symmetry of the enzyme active site. TheExpand
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JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.
We designed, synthesized, and identified JE-2147, an allophenylnorstatine-containing dipeptide HIV protease inhibitor (PI), which is potent against a wide spectrum of HIV-1, HIV-2, simianExpand
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Culturally Responsive Special Education Referrals of English Learners in One Rural County School District: Pilot Project
The project setting was a remote rural county school district located in a mountain western state with some overrepresentation of English Learners (ELs) in special education. Referral issues areExpand
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Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS.
Given the complex involvement of herpesviruses in the pathogenesis of AIDS, an agent capable of controlling the replication of both HIV and herpesviruses may offer special benefits in AIDS therapy.Expand
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Fetal Heart Rate Changes After Intrathecal Sufentanil or Epidural Bupivicaine for Labor Analgesia: Incidence and Clinical Significance
The objective of this study was to compare the incidence of intrapartum fetal heart tracing (FHT) abnormalities and the obstetric outcome after intrathecal sufentanil (ITS) versus epiduralExpand
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In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine.
Transition state mimetic tripeptide human immunodeficiency virus (HIV) protease inhibitors containing allophenylnorstatine [(2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] were synthesized and testedExpand
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Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate.
A series of mutations, first identified in protease inhibitor-resistant HIV-1 viral isolates, were introduced into HIV-1 PR as individual substitutions. Mutants containing R8K, V32I, V82T, I84V,Expand
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Carbamylhydrazine hydrochloride as a lung and blood vessel tumour inducer in Swiss mice.
Abstract Administration of 0·0625% carbamylhydrazine hydrochloride in the drinking water of 6 -week-old, randomly bred Swiss albino mice for the remainder of their lifetimes, enhanced the developmentExpand
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