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Porcine Circoviruses: A Review
  • G. Allan, J. Ellis
  • Biology, Medicine
  • Journal of veterinary diagnostic investigation…
  • 1 January 2000
The diagnosis of PCV2-associated disease is based on the direct demonstration ofPCV2 antigens or nucleic acid in affected tissues, as is the role of the immune response in controlling or augmenting disease. Expand
Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome.
Results demonstrate a high degree of association between the presence of the circovirus-like virus and postweaning multisystemic wasting syndrome in affected swine. Expand
Isolation of Porcine Circovirus-like Viruses from Pigs with a Wasting Disease in the USA and Europe
Although genomic analysis for the definitive identification of these viral isolates remains to be done, the evidence provided strongly suggests that these tissue isolates are closely related to, although antigenically distinct from, the original PCV cell culture contaminant. Expand
Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus.
Jaundice and hepatomegaly were seen at post-mortem examination of most of the dually infected pigs; the latter showed large amounts of PCV2 antigen in numerous tissues; PPV antigen, which was less abundant, was detected in a few tissues, especially kidney. Expand
Characterization of novel circovirus DNAs associated with wasting syndromes in pigs.
Cl cloning and characterization of novel circovirus DNAs purified from virus isolates made from tissues of North American and European pigs with wasting syndromes are reported, providing evidence for a new type of possibly pathogenic PCV. Expand
Activation of the Immune System is the Pivotal Event in the Production of Wasting Disease in Pigs Infected with Porcine Circovirus-2 (PCV-2)
In PMWS-affected piglets, extensive replication of PCV-2 was documented by both immunocytochemistry and quantitative viral titrations, suggesting immune activation is a key component of the pathogenesis of PCv-2-associated PMWS in swine. Expand
PCV-2 genotype definition and nomenclature
The phylogenetic groups of porcine circo-virus type 2 (pcv-2) have been recognised but the mandate of the International Committee on investigates these groups is unclear. Expand
Reproduction of lesions of postweaning multisystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus.
Results indicate that lesions of PMWS can be induced by inoculating pigs with PCV2 alone, thereby fulfilling Koch's postulates. Expand
Viral Wasting Syndrome of Swine: Experimental Reproduction of Postweaning Multisystemic Wasting Syndrome in Gnotobiotic Swine by Coinfection with Porcine Circovirus 2 and Porcine Parvovirus
Production of PMWS in gnotobiotic swine appears to require PCV-2 and additional infectious agents such as PPV for full disease expression in g notobiotic piglets. Expand