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Heterogeneous expression of repolarizing, voltage‐gated K+ currents in adult mouse ventricles
Previous studies have documented the expression of four kinetically distinct voltage‐gated K+ (Kv) currents, Ito,f, Ito,s, IK,slow and Iss, in mouse ventricular myocytes and demonstrated that Ito,fExpand
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The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels
Vernakalant (RSD1235) is an investigational drug recently shown to convert atrial fibrillation rapidly and safely in patients (J Am Coll Cardiol 44:2355–2361, 2004). Here, the molecular mechanisms ofExpand
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  • Open Access
Single-channel basis for the slow activation of the repolarizing cardiac potassium current, IKs
Coassembly of potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) with potassium voltage-gated channel, Isk-related family, member 1 (KCNE1) the delayed rectifier potassium channelExpand
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Kv1.5 Is an Important Component of Repolarizing K+ Current in Canine Atrial Myocytes
Abstract— Although the canine atrium has proven useful in several experimental models of atrial fibrillation and for studying the effects of rapid atrial pacing on atrial electrical remodeling, itExpand
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  • Open Access
A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact
Purpose: Hereditary long QT syndrome is named for a prolonged QT interval reflecting predisposition to ventricular arrhythmias and sudden death. A high rate in a remote, northern Canadian FirstExpand
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Localization of Kv1.5 channels in rat and canine myocyte sarcolemma
Voltage‐gated potassium (Kv) channel subtypes localize to the plasma membrane of a number of cell types, and the sarcolemma in myocytes. Because many signaling molecules concentrate in subdomains ofExpand
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Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
In voltage-activated ion channels, voltage sensor (VSD) activation induces pore opening via VSD-pore coupling. Previous studies show that the pore in KCNQ1 channels opens when the VSD activates toExpand
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  • Open Access
Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs
Long QT interval syndrome (LQTS) type 1 (LQT1) has been reported to arise from mutations in the S3 domain of KCNQ1, but none of the seven S3 mutations in the literature have been characterized withExpand
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Shared requirement for dynein function and intact microtubule cytoskeleton for normal surface expression of cardiac potassium channels.
Potassium channels at the cardiomyocyte surface must eventually be internalized and degraded, and changes in cardiac potassium channel expression are known to occur during myocardial disease. It isExpand
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  • Open Access
Modeling of high-affinity binding of the novel atrial anti-arrhythmic agent, vernakalant, to Kv1.5 channels.
Vernakalant (RSD1235) is an investigational drug that converts atrial fibrillation rapidly and safely in patients intravenously [Roy et al., J. Am. Coll. Cardiol. 44 (2004) 2355-2361; Roy et al.,Expand
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