J. Eiserich

Publications
Influence

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

J. Eiserich, M. Hristova, +4 authors A. Vliet
Chemistry, Medicine
Nature
22 January 1998

Nitric oxide (˙NO) plays a central role in the pathogenesis of diverse inflammatory and infectious disorders,. The toxicity of ˙NO is thought to be engendered, in part, by its reaction with… Expand

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Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium

R. Harper, C. Xu, +5 authors R. Wu
Biology, Medicine
FEBS letters
29 August 2005

Partially reduced metabolites of molecular oxygen, superoxide ( O 2 ‐ ) and hydrogen peroxide (H2O2), are detected in respiratory tract lining fluid, and it is assumed that these are key components… Expand

Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes

S. Baldus, C. Heeschen, +5 authors C. Hamm
Medicine
Circulation
23 September 2003

Background—Polymorphonuclear neutrophils (PMNs) have gained attention as critical mediators of acute coronary syndromes (ACS). Myeloperoxidase (MPO), a hemoprotein abundantly expressed by PMNs and… Expand

Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite

A. van der Vliet, J. Eiserich, B. Halliwell, C. Cross
Chemistry, Medicine
The Journal of Biological Chemistry
21 March 1997

Involvement of peroxynitrite (ONOO−) in inflammatory diseases has been implicated by detection of 3-nitrotyrosine, an allegedly characteristic protein oxidation product, in various inflamed tissues.… Expand

Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease*

P. Brookes, E. Salinas, +4 authors P. Anderson
Chemistry, Medicine
The Journal of Biological Chemistry
7 July 2000

The mitochondrial permeability transition pore (PTP) and associated release of cytochrome c are thought to be important in the apoptotic process. Nitric oxide (NO⋅) has been reported to inhibit… Expand

Soluble epoxide hydrolase is a therapeutic target for acute inflammation.

K. R. Schmelzer, L. Kubala, J. Newman, Inhae Kim, J. Eiserich, B. Hammock
Chemistry, Medicine
Proceedings of the National Academy of Sciences…
12 July 2005

As of 2004, >73 million people were prescribed antiinflammatory medication. Despite the extensive number of current products, many people still suffer from their diseases or the pharmacological… Expand

Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

J. Eiserich, S. Baldus, +8 authors B. Freeman
Biology, Medicine
Science
28 June 2002

Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. Although its microbicidal functions are well established in vitro, humans… Expand

Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.

D. Lau, H. Mollnau, +9 authors S. Baldus
Biology, Medicine
Proceedings of the National Academy of Sciences…
11 January 2005

Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens and has also emerged as a hallmark of vascular inflammation. One of… Expand

Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease?

A. van der Vliet, J. Eiserich, M. Shigenaga, C. Cross
Medicine
American journal of respiratory and critical care…
1 July 1999

Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors

K. R. Schmelzer, B. Inceoğlu, +4 authors B. Hammock
Chemistry, Medicine
Proceedings of the National Academy of Sciences
12 September 2006

Combination therapies have long been used to treat inflammation while reducing side effects. The present study was designed to evaluate the therapeutic potential of combination treatment with… Expand

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