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Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
Nitric oxide (˙NO) plays a central role in the pathogenesis of diverse inflammatory and infectious disorders,. The toxicity of ˙NO is thought to be engendered, in part, by its reaction withExpand
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Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium
Partially reduced metabolites of molecular oxygen, superoxide ( O 2 ‐ ) and hydrogen peroxide (H2O2), are detected in respiratory tract lining fluid, and it is assumed that these are key componentsExpand
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Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes
Background—Polymorphonuclear neutrophils (PMNs) have gained attention as critical mediators of acute coronary syndromes (ACS). Myeloperoxidase (MPO), a hemoprotein abundantly expressed by PMNs andExpand
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Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite
Involvement of peroxynitrite (ONOO−) in inflammatory diseases has been implicated by detection of 3-nitrotyrosine, an allegedly characteristic protein oxidation product, in various inflamed tissues.Expand
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Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease*
The mitochondrial permeability transition pore (PTP) and associated release of cytochrome c are thought to be important in the apoptotic process. Nitric oxide (NO⋅) has been reported to inhibitExpand
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Soluble epoxide hydrolase is a therapeutic target for acute inflammation.
As of 2004, >73 million people were prescribed antiinflammatory medication. Despite the extensive number of current products, many people still suffer from their diseases or the pharmacologicalExpand
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Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase
Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. Although its microbicidal functions are well established in vitro, humansExpand
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Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens and has also emerged as a hallmark of vascular inflammation. One ofExpand
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Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors
Combination therapies have long been used to treat inflammation while reducing side effects. The present study was designed to evaluate the therapeutic potential of combination treatment withExpand
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