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Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery.
- J. Eisenbrey, O. Burstein, R. Kambhampati, F. Forsberg, J. Liu, M. Wheatley
- Medicine, Chemistry
- Journal of controlled release : official journal…
- 2 April 2010
An echogenic, intravenous drug delivery platform is proposed in which an encapsulated chemotherapeutic can travel to a desired location and drug delivery can be triggered using external, focused… Expand
Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery.
- Michael C. Cochran, J. Eisenbrey, Richard O. Ouma, M. Soulen, Margaret A. Wheatley
- Chemistry, Medicine
- International journal of pharmaceutics
- 29 July 2011
A polymer ultrasound contrast agent (UCA) developed in our lab has been shown to greatly reduce in size when exposed to ultrasound, resulting in nanoparticles less than 400 nm in diameter capable of… Expand
Simultaneous grayscale and subharmonic ultrasound imaging on a modified commercial scanner.
OBJECTIVE To demonstrate the feasibility of simultaneous dual fundamental grayscale and subharmonic imaging on a modified commercial scanner. MOTIVATION The ability to generate signals at half the… Expand
Three-dimensional subharmonic ultrasound imaging in vitro and in vivo.
RATIONALE AND OBJECTIVES Although contrast-enhanced ultrasound imaging techniques such as harmonic imaging (HI) have evolved to reduce tissue signals using the nonlinear properties of the contrast… Expand
Noninvasive LV pressure estimation using subharmonic emissions from microbubbles.
- J. Dave, Valgerdur G. Halldorsdottir, +7 authors F. Forsberg
- JACC. Cardiovascular imaging
To develop a new noninvasive approach to quantify left ventricular (LV) pressures using subharmonic emissions from microbubbles, an ultrasound scanner was used in pulse inversion grayscale mode;… Expand
Perfusion Estimation Using Contrast-Enhanced 3-dimensional Subharmonic Ultrasound Imaging: An In Vivo Study
ObjectivesThe ability to estimate tissue perfusion (in milliliter per minute per gram) in vivo using contrast-enhanced 3-dimensional (3D) harmonic and subharmonic ultrasound imaging was investigated.… Expand
Disposition of ultrasound sensitive polymeric drug carrier in a rat hepatocellular carcinoma model.
RATIONALE AND OBJECTIVES A doxorubicin-loaded microbubble has been developed that can be destroyed with focused ultrasound resulting in fragments, or "nanoshards" capable of escaping through the… Expand
Chronic liver disease: noninvasive subharmonic aided pressure estimation of hepatic venous pressure gradient.
PURPOSE To compare subharmonic aided pressure estimation (SHAPE) with pressure catheter-based measurements in human patients with chronic liver disease undergoing transjugular liver biopsy. … Expand
Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents.
Traditional chemotherapy generally results in systemic toxicity, which also limits drug levels at the area of need. Two ultrasound contrast agents (UCA), with diameters between 1-2 microm in diameter… Expand
Contrast‐Enhanced Sonography for Detection of Secondary Lymph Nodes in a Melanoma Tumor Animal Model
- J. Liu, D. Merton, +6 authors B. Goldberg
- Journal of ultrasound in medicine : official…
- 1 June 2014
To investigate the use of contrast‐enhanced ultrasound imaging (US) for detection of secondary lymph nodes (LNs) in a naturally occurring melanoma swine model compared to surgery and pathologic… Expand