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Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor
Nerve growth factor (NGF) is critical for the development and maintenance of sympathetic and sensory neurons in the developing nervous system, including nociceptors. In the adult nervous system, NGFExpand
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Protective effects of methyl gallate on H2O2-induced apoptosis in PC12 cells.
Neurodegenerative disorders are a class of diseases that have been linked to apoptosis induced by elevated levels of reactive oxygen species (ROS). ROS activates the apoptotic cascade throughExpand
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Multipotent Neurotrophin Antagonist Targets Brain-Derived Neurotrophic Factor and Nerve Growth Factor
Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are members of the neurotrophin family that normally play a role in the development and maintenance of the nervous system.Expand
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The State of Opioid Agonist Therapy in Canada 20 Years after Federal Oversight
Opioid agonist therapy was introduced in Canada in 1959 with the use of methadone for the treatment of opioid dependence. The regulation of methadone was the responsibility of Health Canada untilExpand
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Evaluating the Effectiveness of First-Time Methadone Maintenance Therapy Across Northern, Rural, and Urban Regions of Ontario, Canada
Objectives:Our objective was to determine the impact that a patient's geographic status has on the efficacy of first-time methadone maintenance therapy (MMT) retention. Methods:We conducted anExpand
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Protective effects of polyphenolic compounds on oxidative stress-induced cytotoxicity in PC12 cells.
To investigate the beneficial properties associated with polyphenols, we screened 12 polyphenols for their ability to increase the viability of PC12 cells subjected to oxidative stress via CoCl2 andExpand
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The opioid crisis: past, present and future policy climate in Ontario, Canada
BackgroundAddressing opioid use disorder has become a priority in Ontario, Canada, because of its high economic, social and health burden. There continues to be stigma and criticism relating toExpand
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Bioprospecting for acidophilic lipid-rich green microalgae isolated from abandoned mine site water bodies
With fossil fuel sources in limited supply, microalgae show tremendous promise as a carbon neutral source of biofuel. Current microalgae biofuel strategies typically rely on growing high-lipidExpand
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The impact of cocaine use in patients enrolled in opioid agonist therapy in Ontario, Canada.
BACKGROUND Opioid agonist therapy is the gold standard of care for opioid use disorder; however, the efficacy of this treatment may be hindered by concurrent drug use, including the use of cocaine.Expand
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Improved treatment-retention for patients receiving methadone dosing within the clinic providing physician and other health services (onsite) versus dosing at community (offsite) pharmacies.
OBJECTIVE Opioid-use disorder has been declared a public health crisis across North America. One of the most common treatments for opioid-use disorder is opioid agonist therapy, including MMT. ThisExpand
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